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Caroline L Relton
Researcher at University of Bristol
Publications - 433
Citations - 25612
Caroline L Relton is an academic researcher from University of Bristol. The author has contributed to research in topics: DNA methylation & Mendelian randomization. The author has an hindex of 71, co-authored 394 publications receiving 17221 citations. Previous affiliations of Caroline L Relton include Health Science University & University of Newcastle.
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Journal ArticleDOI
A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57.
Rachelle E Irwin,Sara-Jayne Thursby,Miroslava Ondičová,Kristina Pentieva,Helene McNulty,Rebecca C Richmond,Aoife Caffrey,Diane J. Lees-Murdock,Marian McLaughlin,Tony Cassidy,Matthew Suderman,Caroline L Relton,Colum P. Walsh +12 more
TL;DR: These results strengthen the link between folic acid supplementation during later pregnancy and epigenetic changes and identify a novel mechanism for regulation of ZFP57.
Journal ArticleDOI
Changes in DNA methylation from pre- to post-adolescence are associated with pubertal exposures.
Luhang Han,Hongmei Zhang,Akhilesh Kaushal,Faisal I. Rezwan,Latha Kadalayil,Wilfried Karmaus,A. John Henderson,Caroline L Relton,Susan M. Ring,S. Hasan Arshad,S. Hasan Arshad,Susan Ewart,John W. Holloway +12 more
TL;DR: Identified pathways emphasize the importance of this period of transition on epigenetic state of genes relevant to cell growth and immune system development and significant biological pathways related to growth and development of the reproductive system are identified.
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Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data
Richard Howey,So-Youn Shin,So-Youn Shin,Caroline L Relton,George Davey Smith,Heather J. Cordell +5 more
TL;DR: It is concluded that BN incorporating genetic anchors is a useful complementary method to conventional MR for exploring causal relationships in complex data sets such as those generated from modern “omics” technologies.
Journal ArticleDOI
DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts.
Diana L Juvinao-Quintero,Riccardo E. Marioni,Carolina Ochoa-Rosales,Carolina Ochoa-Rosales,Tom C. Russ,Ian J. Deary,Joyce B. J. van Meurs,Trudy Voortman,Marie-France Hivert,Gemma C Sharp,Caroline L Relton,Hannah R Elliott +11 more
TL;DR: In this article, a meta-analysis of individual epigenome-wide association studies (EWAS) of prevalent Type 2 diabetes (T2D) conducted in four European studies using peripheral blood DNAm.
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Smoking, Secondhand Smoke, and Cotinine Levels in a Subset of EPIC Cohort
Valéria Troncoso Baltar,Wei W. Xun,Shu Chun Chuang,Caroline L Relton,Per Magne Ueland,Stein Emil Vollset,Øivind Midttun,Mattias Johansson,Nadia Slimani,Mazda Jenab,Fraņcoise Clavel-Chapelon,Fraņcoise Clavel-Chapelon,Marie-Christine Boutron-Ruault,Marie-Christine Boutron-Ruault,Guy Fagherazzi,Guy Fagherazzi,Rudolf Kaaks,Sabine Rohrmann,Heiner Boeing,Cornelia Weikert,H. Bas Bueno-de-Mesquita,Hendriek C. Boshuizen,Carla H. van Gils,Petra H.M. Peeters,Antonio Agudo,Aurelio Barricarte,Carmen Navarro,Laudina Rodríguez,José María Huerta Castaño,Nerea Larrañaga,María José Pérez,Kay-Tee Khaw,Nicholas J. Wareham,Naomi E. Allen,Francesca L. Crowe,Valentina Gallo,Teresa Norat,Giovanna Tagliabue,Giovanna Masala,Salvatore Panico,Carlota Sacerdote,Rosario Tumino,Antonia Trichopoulou,Pagona Lagiou,Pagona Lagiou,Christina Bamia,Torgny Rasmuson,Göran Hallmans,Nina Roswall,Anne Tjønneland,Elio Riboli,Paul Brennan,Paolo Vineis +52 more
TL;DR: There is clear evidence that not only tobacco smoking but also involuntary exposure increases cotinine levels, which strengthens the evidence for the benefits of a smoking ban in public places.