Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging.
Thomas D. Parker,Catherine F. Slattery,Jiaying Zhang,Jennifer M. Nicholas,Ross W. Paterson,Alexander J.M. Foulkes,Ian B. Malone,David L. Thomas,Marc Modat,David M. Cash,Sebastian J. Crutch,Daniel C. Alexander,Sebastien Ourselin,Nick C. Fox,Hui Zhang,Jonathan M. Schott +15 more
TLDR
Data suggest distinct differences in cortical NDI and ODI occur in AD and these metrics provide pathologically relevant information beyond that of cortical thinning.Abstract:
Alzheimer's disease (AD) is associated with extensive alterations in grey matter microstructure, but our ability to quantify this in vivo is limited. Neurite orientation dispersion and density imaging (NODDI) is a multi-shell diffusion MRI technique that estimates neuritic microstructure in the form of orientation dispersion and neurite density indices (ODI/NDI). Mean values for cortical thickness, ODI, and NDI were extracted from predefined regions of interest in the cortical grey matter of 38 patients with young onset AD and 22 healthy controls. Five cortical regions associated with early atrophy in AD (entorhinal cortex, inferior temporal gyrus, middle temporal gyrus, fusiform gyrus, and precuneus) and one region relatively spared from atrophy in AD (precentral gyrus) were investigated. ODI, NDI, and cortical thickness values were compared between controls and patients for each region, and their associations with MMSE score were assessed. NDI values of all regions were significantly lower in patients. Cortical thickness measurements were significantly lower in patients in regions associated with early atrophy in AD, but not in the precentral gyrus. Decreased ODI was evident in patients in the inferior and middle temporal gyri, fusiform gyrus, and precuneus. The majority of AD-related decreases in cortical ODI and NDI persisted following adjustment for cortical thickness, as well as each other. There was evidence in the patient group that cortical NDI was associated with MMSE performance. These data suggest distinct differences in cortical NDI and ODI occur in AD and these metrics provide pathologically relevant information beyond that of cortical thinning.read more
Citations
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The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals
Bradford C. Dickerson,Akram Bakkour,David H. Salat,Eric Feczko,Jenni Pacheco,Douglas N. Greve,Fran Grodstein,Christopher I. Wright,Christopher I. Wright,Deborah Blacker,H. Diana Rosas,Reisa A. Sperling,Alireza Atri,John H. Growdon,Bradley T. Hyman,John C. Morris,Bruce Fischl,Bruce Fischl,Randy L. Buckner,Randy L. Buckner +19 more
TL;DR: Results demonstrate a reliably quantifiable in vivo signature of abnormal cortical anatomy in AD, which parallels known regional vulnerability to AD neuropathology, and may provide a powerful methodological framework for studies of neuropsychiatric diseases.
Journal ArticleDOI
SANDI: a compartment-based model for non-invasive apparent soma and neurite imaging by diffusion MRI.
Marco Palombo,Andrada Ianus,Michele Guerreri,Daniel Nunes,Daniel C. Alexander,Noam Shemesh,Hui Zhang +6 more
TL;DR: In this paper, a compartment-based model for apparent cell body (namely soma) and neurite density imaging (SANDI) using non-invasive diffusion-weighted MRI (DW-MRI) was introduced.
Journal ArticleDOI
NODDI in clinical research.
TL;DR: The applications of NODDI in clinical research are reviewed and future perspectives for investigations toward the implementation of dMRI microstructure imaging in clinical practice are discussed.
Journal ArticleDOI
Diffusion MRI Indices and Their Relation to Cognitive Impairment in Brain Aging: The Updated Multi-protocol Approach in ADNI3
Artemis Zavaliangos-Petropulu,Talia M. Nir,Sophia I. Thomopoulos,Robert I. Reid,Matt A. Bernstein,Bret J. Borowski,Clifford R. Jack,Michael W. Weiner,Neda Jahanshad,Paul M. Thompson +9 more
TL;DR: Across all dMRI indices and clinical measures, the hippocampal-cingulum and fornix (crus)/stria terminalis regions most consistently showed strong associations with clinical impairment, while FADTI was the weakest of the five indices for detecting associations.
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