John R. McPherson

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet- base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

TL;DR: Somatic inactivation of FAT4 and ARID1A may be key tumorigenic events in a subset of gastric cancers, and cell adhesion was the most enriched biological pathway among the frequently mutated genes.

TL;DR: In this paper, the authors analyzed 489 cholangiocarcinoma (CCA) from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information.

TL;DR: Insight into the mutational landscape contributing to O. viverrini–related CCA is provided and 206 somatic mutations in 187 genes using Sanger sequencing are identified and selected 15 genes for mutation prevalence screening in an additional 46 individuals with CCA.