S
Ser Yee Lee
Researcher at Singapore General Hospital
Publications - 166
Citations - 4416
Ser Yee Lee is an academic researcher from Singapore General Hospital. The author has contributed to research in topics: Hepatectomy & Miscibility. The author has an hindex of 31, co-authored 164 publications receiving 3392 citations. Previous affiliations of Ser Yee Lee include Van Andel Institute & NewYork–Presbyterian Hospital.
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Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers
Waraporn Chan-on,Waraporn Chan-on,Maarja-Liisa Nairismagi,Choon Kiat Ong,Weng Khong Lim,Simona Dima,Chawalit Pairojkul,Kiat Hon Lim,John R. McPherson,Ioana Cutcutache,Hong Lee Heng,London L.P.J. Ooi,Alexander Y. F. Chung,Pierce K. H. Chow,Peng Chung Cheow,Ser Yee Lee,Su Pin Choo,Iain Beehuat Tan,Dan G. Duda,Anca Nastase,Swe Swe Myint,Bernice Huimin Wong,Anna Gan,Vikneswari Rajasegaran,Cedric Chuan Young Ng,Sanjanaa Nagarajan,Apinya Jusakul,Shenli Zhang,Priya Vohra,Willie Yu,Dachuan Huang,Paiboon Sithithaworn,Puangrat Yongvanit,Sopit Wongkham,Narong Khuntikeo,Vajaraphongsa Bhudhisawasdi,Irinel Popescu,Steven G. Rozen,Patrick Tan,Patrick Tan,Bin Tean Teh +40 more
TL;DR: Functional studies demonstrated tumor suppressive functions for BAP1 and ARID1A, establishing the role of chromatin modulators in CCA pathogenesis and indicating that different causative etiologies may induce distinct somatic alterations, even within the same tumor type.
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A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures
Michael Thomas Wong,David E. Ong,Frances Sheau Huei Lim,Karen Wei Weng Teng,Naomi McGovern,Sriram Narayanan,Wen Qi Ho,Daniela Cerny,Daniela Cerny,Henry K.K. Tan,Rosslyn Anicete,Bien Keem Tan,Tony Kiat Hon Lim,Chung Yip Chan,Peng Chung Cheow,Ser Yee Lee,Angela Takano,Eng Huat Tan,John Kit Chung Tam,Ern Yu Tan,Jerry Kok Yen Chan,Katja Fink,Antonio Bertoletti,Antonio Bertoletti,Florent Ginhoux,Maria A. Curotto de Lafaille,Evan W. Newell +26 more
TL;DR: Mass cytometry is utilized to simultaneously analyze T cell trafficking and functional markers across eight different human tissues, revealing a plethora of tissue immune signatures and providing a systemic map of how T-cell phenotypes are altered throughout the human body.
Journal ArticleDOI
Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma
Chun Jye Lim,Yun Hua Lee,Lu Pan,Liyun Lai,Camillus Chua,Martin Wasser,Tony Kiat-Hon Lim,Tony Kiat-Hon Lim,Joe Yeong,Joe Yeong,Han Chong Toh,Ser Yee Lee,Chung Yip Chan,Brian K. P. Goh,Alexander Y. F. Chung,Mathias Heikenwalder,Irene Ol Ng,Pierce K. H. Chow,Salvatore Albani,Valerie Chew +19 more
TL;DR: It is shown that the HBV- related HCC microenvironment is more immunosuppressive and exhausted than the non-viral-related HCCMicroenvironment, and TREG and TRM contributed to overall patient survival: TREG were associated with a poor prognosis andTRM were associatedWith a good prognosis in HCC.
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Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses.
Valerie Chew,Liyun Lai,Lu Pan,Chun Jye Lim,Juntao Li,Raymond Ong,Camillus Chua,Jing Yao Leong,Kiat Hon Lim,Kiat Hon Lim,Han Chong Toh,Ser Yee Lee,Ser Yee Lee,Chung Yip Chan,Chung Yip Chan,Brian K. P. Goh,Brian K. P. Goh,Alexander Y. F. Chung,Alexander Y. F. Chung,Pierce K. H. Chow,Pierce K. H. Chow,Salvatore Albani +21 more
TL;DR: The existence of an immunosuppressive gradient across the TME, NTME, and peripheral blood in primary HCC that manipulates the activation status of tumor-infiltrating leukocytes and renders them immunocompromised against tumor cells is confirmed.
Journal ArticleDOI
Distal Pancreatectomy: A Single Institution's Experience in Open, Laparoscopic, and Robotic Approaches
Ser Yee Lee,Peter J. Allen,Eran Sadot,Michael I. D’Angelica,Ronald P. DeMatteo,Yuman Fong,William R. Jarnagin,T. Peter Kingham +7 more
TL;DR: The RDP and LDP were comparable with respect to most perioperative outcomes, with no clear advantage of one approach over the other.