A
Alexander Y. F. Chung
Researcher at Singapore General Hospital
Publications - 179
Citations - 6690
Alexander Y. F. Chung is an academic researcher from Singapore General Hospital. The author has contributed to research in topics: Hepatocellular carcinoma & Hepatectomy. The author has an hindex of 39, co-authored 165 publications receiving 4955 citations. Previous affiliations of Alexander Y. F. Chung include National University of Singapore.
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Journal ArticleDOI
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
Apinya Jusakul,Apinya Jusakul,Ioana Cutcutache,Chern Han Yong,Jing Quan Lim,Mi Ni Huang,Nisha Padmanabhan,Vishwa Nellore,Sarinya Kongpetch,Alvin Wei Tian Ng,Ley Moy Ng,Su Pin Choo,Swe Swe Myint,Raynoo Thanan,Sanjanaa Nagarajan,Weng Khong Lim,Cedric Chuan Young Ng,Arnoud Boot,Mo Liu,Choon Kiat Ong,Vikneswari Rajasegaran,Stefanus Lie,Alvin Soon Tiong Lim,Tse Hui Lim,Jing Tan,Jia Liang Loh,John R. McPherson,Narong Khuntikeo,Vajaraphongsa Bhudhisawasdi,Puangrat Yongvanit,Sopit Wongkham,Yasushi Totoki,Hiromi Nakamura,Yasuhito Arai,Satoshi Yamasaki,Pierce K. H. Chow,Alexander Y. F. Chung,London L.P.J. Ooi,Kiat Hon Lim,Simona Dima,Dan G. Duda,Irinel Popescu,Philippe Broët,Sen-Yung Hsieh,Ming-Chin Yu,Aldo Scarpa,Jiaming Lai,Di-Xian Luo,André Lopes Carvalho,André Luiz Vettore,Hyungjin Rhee,Young Nyun Park,Ludmil B. Alexandrov,Raluca Gordân,Steven G. Rozen,Tatsuhiro Shibata,Chawalit Pairojkul,Bin Tean Teh,Patrick Tan +58 more
TL;DR: In this paper, the authors analyzed 489 cholangiocarcinoma (CCA) from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information.
Journal ArticleDOI
Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers
Waraporn Chan-on,Waraporn Chan-on,Maarja-Liisa Nairismagi,Choon Kiat Ong,Weng Khong Lim,Simona Dima,Chawalit Pairojkul,Kiat Hon Lim,John R. McPherson,Ioana Cutcutache,Hong Lee Heng,London L.P.J. Ooi,Alexander Y. F. Chung,Pierce K. H. Chow,Peng Chung Cheow,Ser Yee Lee,Su Pin Choo,Iain Beehuat Tan,Dan G. Duda,Anca Nastase,Swe Swe Myint,Bernice Huimin Wong,Anna Gan,Vikneswari Rajasegaran,Cedric Chuan Young Ng,Sanjanaa Nagarajan,Apinya Jusakul,Shenli Zhang,Priya Vohra,Willie Yu,Dachuan Huang,Paiboon Sithithaworn,Puangrat Yongvanit,Sopit Wongkham,Narong Khuntikeo,Vajaraphongsa Bhudhisawasdi,Irinel Popescu,Steven G. Rozen,Patrick Tan,Patrick Tan,Bin Tean Teh +40 more
TL;DR: Functional studies demonstrated tumor suppressive functions for BAP1 and ARID1A, establishing the role of chromatin modulators in CCA pathogenesis and indicating that different causative etiologies may induce distinct somatic alterations, even within the same tumor type.
Journal ArticleDOI
Microvascular invasion is a better predictor of tumor recurrence and overall survival following surgical resection for hepatocellular carcinoma compared to the Milan criteria.
Kheng-Choon Lim,Pierce K. H. Chow,John Carson Allen,Ghim-Song Chia,Miaoshan Lim,Peng-Chung Cheow,Alexander Y. F. Chung,London L.P.J. Ooi,Say Beng Tan +8 more
TL;DR: Assessment of McVI should aid in patient selection for adjuvant treatments to improve outcomes after SR and show that McVI is a better predictor of tumor recurrence and OS than the Milan criteria after SR for HCC.
Journal ArticleDOI
Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma
Marta Garnelo,Alex Tan,Zhisheng Her,Joe Yeong,Joe Yeong,Chun Jye Lim,Jinmiao Chen,Kiat Hon Lim,Achim Weber,Pierce K. H. Chow,Pierce K. H. Chow,Alexander Y. F. Chung,London Lucien Pj Ooi,London Lucien Pj Ooi,Han Chong Toh,Mathias Heikenwalder,Irene Oi-Lin Ng,Alessandra Nardin,Qingfeng Chen,Jean-Pierre Abastado,Valerie Chew,Valerie Chew,Valerie Chew +22 more
TL;DR: The close proximity of tumour-infiltrating T cells and B cells indicates a functional interaction between them that is linked to an enhanced local immune activation and contributes to better prognosis for patients with HCC.
Journal ArticleDOI
Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3
Yu Wang,Yiwei Lu,Soo Ting Toh,Wing-Kin Sung,Wing-Kin Sung,Patrick Tan,Patrick Tan,Pierce K. H. Chow,Pierce K. H. Chow,Alexander Y. F. Chung,London L.P. Jooi,Caroline G.L. Lee +11 more
TL;DR: The deregulation of the expression of the let-7 family of miRNAs by HBx may represent a potential novel pathway through which HBx acts to deregulate cell proliferation leading to hepatocarcinogenesis.