A
Akiko Yabuuchi
Researcher at Harvard University
Publications - 20
Citations - 5308
Akiko Yabuuchi is an academic researcher from Harvard University. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 14, co-authored 19 publications receiving 5080 citations. Previous affiliations of Akiko Yabuuchi include Boston Children's Hospital & Brigham and Women's Hospital.
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Journal ArticleDOI
Reprogramming of human somatic cells to pluripotency with defined factors
In-Hyun Park,In-Hyun Park,Rui Zhao,Rui Zhao,Jason A. West,Jason A. West,Akiko Yabuuchi,Akiko Yabuuchi,Hongguang Huo,Hongguang Huo,Tan A. Ince,Paul H. Lerou,M. William Lensch,M. William Lensch,George Q. Daley,George Q. Daley +15 more
TL;DR: The data demonstrate that defined factors can reprogramme human cells to pluripotency, and establish a method whereby patient-specific cells might be established in culture.
Journal ArticleDOI
Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells
Kian Peng Koh,Akiko Yabuuchi,Sridhar Rao,Yun Huang,Kerrianne Cunniff,Julie Nardone,Asta Laiho,Mamta Tahiliani,Cesar Sommer,Gustavo Mostoslavsky,Riitta Lahesmaa,Riitta Lahesmaa,Stuart H. Orkin,Stuart H. Orkin,Stuart H. Orkin,Scott J. Rodig,George Q. Daley,Anjana Rao +17 more
TL;DR: 5hmC is an epigenetic modification associated with the pluripotent state, and Tet1 functions to regulate the lineage differentiation potential of ESCs.
Journal ArticleDOI
A role for Lin28 in primordial germ-cell development and germ-cell malignancy
Jason A. West,Srinivas R. Viswanathan,Akiko Yabuuchi,Kerianne Cunniff,Ayumu Takeuchi,In-Hyun Park,Julia E. Sero,Hao Zhu,Antonio R. Perez-Atayde,A. Lindsay Frazier,M. Azim Surani,George Q. Daley,George Q. Daley +12 more
TL;DR: It is shown that Blimp1 (also called Prdm1), a let-7 target and a master regulator of PGC specification, can rescue the effect of Lin28 deficiency during PGC development, thereby establishing a mechanism of action for Lin28 during P GC specification.
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The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells
Yu-Fen Chou,Hsu-Hsin Chen,Maureen Eijpe,Akiko Yabuuchi,Josh G. Chenoweth,Paul J. Tesar,Jun Lu,Ronald D.G. McKay,Niels Geijsen +8 more
TL;DR: The findings indicate that novel stem cell lines, with unique functional and molecular properties, can be generated from murine blastocyst embryos and demonstrate that the culture growth factor environment and cell-cell interaction play a critical role in defining several unique and stable stem cell ground states.
Journal ArticleDOI
Histocompatible Embryonic Stem Cells by Parthenogenesis
Kitai Kim,Paul H. Lerou,Paul H. Lerou,Akiko Yabuuchi,Claudia Lengerke,Kitwa Ng,Jason A. West,Andrew Kirby,Mark J. Daly,George Q. Daley +9 more
TL;DR: Differentiated tissues from these pES cells engrafted in immunocompetent MHC-matched mouse recipients are distinguished, demonstrating that selected p ES cells can serve as a source of histocompatible tissues for transplantation.