C
Chad Haynes
Researcher at Rockefeller University
Publications - 28
Citations - 8071
Chad Haynes is an academic researcher from Rockefeller University. The author has contributed to research in topics: Sample size determination & Genetic model. The author has an hindex of 18, co-authored 28 publications receiving 7551 citations.
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Journal ArticleDOI
Complement Factor H Polymorphism in Age-Related Macular Degeneration
Robert J. Klein,Caroline J. Zeiss,Emily Y. Chew,Jen-yue Tsai,Richard S. Sackler,Chad Haynes,A. K. Henning,John Paul SanGiovanni,Shrikant Mane,Susan T. Mayne,Michael B. Bracken,Frederick L. Ferris,Jurg Ott,Colin J. Barnstable,Josephine Hoh +14 more
TL;DR: A genome-wide screen for polymorphisms associated with age-related macular degeneration revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402 in the complement factor H gene.
Journal ArticleDOI
Complement factor H polymorphism in age-related macular degeneration
Robert J. Klein,C. Zeiss,Emily Y. Chew,J.Y. Tsai,Richard S. Sackler,Chad Haynes,A. K. Henning,John Paul SanGiovanni,S.M. Manne,S.T. Mayne,Michael B. Bracken,Frederick L. Ferris,Jurg Ott,Colin J. Barnstable,Josephine Hoh +14 more
TL;DR: A genome-wide screen for polymorphisms associated with age-related macular degeneration revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402 in the complement factor H gene.
Journal ArticleDOI
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes.
Chad Haynes,Christopher J. Oldfield,Fei Ji,Niels Klitgord,Michael E. Cusick,Predrag Radivojac,Vladimir N. Uversky,Vladimir N. Uversky,Marc Vidal,Lilia M. Iakoucheva +9 more
TL;DR: The results of this study demonstrate that intrinsic structural disorder is a distinctive and common characteristic of eukaryotic hub proteins, and that disorder may serve as a determinant of protein interactivity.
Journal ArticleDOI
Identification, Analysis and Prediction of Protein Ubiquitination Sites
Predrag Radivojac,Vladimir Vacic,Chad Haynes,Ross Cocklin,Amrita Mohan,Joshua W. Heyen,Mark G. Goebl,Lilia M. Iakoucheva +7 more
TL;DR: It is shown that gain and loss of predicted ubiquitination sites may likely represent a molecular mechanism behind a number of disease‐associatedmutations.
Journal ArticleDOI
Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata.
Amalia Martinez-Mir,Abraham Zlotogorski,Derek Gordon,Lynn Petukhova,Jianhong Mo,T. Conrad Gilliam,Douglas Londono,Chad Haynes,Jurg Ott,Maria K. Hordinsky,Krassimira Nanova,David A. Norris,Vera H. Price,Madeleine Duvic,Angela M. Christiano +14 more
TL;DR: A genomewide search for linkage in 20 families with AA revealed evidence of at least four susceptibility loci on chromosomes 6, 10, 16 and 18, which suggest that these regions may harbor gene(s) involved in a number of different skin and hair disorders.