L
Lynn Petukhova
Researcher at Columbia University
Publications - 52
Citations - 3635
Lynn Petukhova is an academic researcher from Columbia University. The author has contributed to research in topics: Alopecia areata & Hair follicle. The author has an hindex of 22, co-authored 43 publications receiving 2952 citations. Previous affiliations of Lynn Petukhova include Rockefeller University.
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Journal ArticleDOI
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition
Luzhou Xing,Z. Dai,Ali Jabbari,Jane E. Cerise,Claire A. Higgins,Weijuan Gong,Annemieke de Jong,Sivan Harel,Gina M. DeStefano,Lisa Rothman,Pallavi Singh,Lynn Petukhova,Julian Mackay-Wiggan,Angela M. Christiano,Raphael Clynes +14 more
TL;DR: It is shown that cytotoxic CD8+NKG2D+ T cells are both necessary and sufficient for the induction of AA in mouse models of disease, suggesting the potential clinical utility of JAK inhibition in human AA.
Journal ArticleDOI
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
Lynn Petukhova,Madeleine Duvic,Maria K. Hordinsky,David A. Norris,Vera H. Price,Yutaka Shimomura,Hyunmi Kim,Pallavi Singh,Annette Lee,Wei V. Chen,K.C. Meyer,Ralf Paus,Ralf Paus,Colin A.B. Jahoda,Christopher I. Amos,Peter K. Gregersen,Angela M. Christiano +16 more
TL;DR: The genetic underpinnings of AA are defined, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity.
Journal ArticleDOI
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
Philip C Haycock,Stephen Burgess,Aayah Nounu,Jie Zheng,G N Okoli,Jack Bowden,Kaitlin H Wade,Nicholas J. Timpson,David M. Evans,Peter Willeit,Abraham Aviv,Tom R. Gaunt,Gibran Hemani,Massimo Mangino,Hayley P Ellis,Kathreena M Kurian,Karen A. Pooley,Rosalind A. Eeles,Jeffrey E. Lee,Shenying Fang,Wei V. Chen,Matthew Law,Lisa Bowdler,Mark M. Iles,Qiong Yang,Bradford B. Worrall,Hugh S. Markus,Rayjean J. Hung,Christopher I. Amos,Amanda B. Spurdle,Deborah J. Thompson,Tracy A. O'Mara,Brian M. Wolpin,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Antonia Trichopoulou,N. Charlotte Onland-Moret,Eiliv Lund,Eric J. Duell,Federico Canzian,Gianluca Severi,Kim Overvad,Marc J. Gunter,Rosario Tumino,Ulrika Svenson,Andre M. van Rij,Annette F. Baas,Matthew J. Bown,Nilesh J. Samani,Femke N G van t'Hof,Gerard Tromp,Gregory T. Jones,Helena Kuivaniemi,James R. Elmore,Mattias Johansson,James McKay,Ghislaine Scelo,Robert Carreras-Torres,Valerie Gaborieau,Paul Brennan,Paige M. Bracci,Rachel E. Neale,Sara H. Olson,Steven Gallinger,Donghui Li,Gloria M. Petersen,Harvey A. Risch,Alison P. Klein,Jiali Han,Christian C. Abnet,Neal D. Freedman,Philip R. Taylor,John M. Maris,Katja K.H. Aben,Lambertus A. Kiemeney,Sita H. Vermeulen,John K. Wiencke,Kyle M. Walsh,Margaret Wrensch,Terri Rice,Clare Turnbull,Kevin Litchfield,Lavinia Paternoster,Marie Standl,Gonçalo R. Abecasis,John Paul SanGiovanni,Yong Li,Vladan Mijatovic,Yadav Sapkota,Siew-Kee Low,Krina T. Zondervan,Grant W. Montgomery,Dale R. Nyholt,David A. van Heel,Karen A. Hunt,Dan E. Arking,Foram N. Ashar,Nona Sotoodehnia,Daniel Woo,Jonathan Rosand,Mary E. Comeau,W. Mark Brown,Edwin K. Silverman,John E. Hokanson,Michael H. Cho,Jennie Hui,Manuel A. R. Ferreira,Philip J. Thompson,Alanna C. Morrison,Janine F. Felix,Nicholas L. Smith,Angela M. Christiano,Lynn Petukhova,Regina C. Betz,Xing Fan,Xuejun Zhang,Caihong Zhu,Carl D. Langefeld,Susan D. Thompson,Feijie Wang,Xu Lin,David A. Schwartz,Tasha E. Fingerlin,Jerome I. Rotter,Mary Frances Cotch,Richard A. Jensen,Matthias Munz,Henrik Dommisch,Arne S. Schaefer,Fang Han,Hanna Ollila,Ryan P. Hillary,Omar M. E. Albagha,Stuart H. Ralston,Chenjie Zeng,Wei Zheng,Xiao-Ou Shu,André Reis,Steffen Uebe,Ulrike Hüffmeier,Yoshiya Kawamura,Takeshi Otowa,Tsukasa Sasaki,Martin L. Hibberd,Sonia Davila,Gang Xie,Katherine A. Siminovitch,Jin-Xin Bei,Yi Xin Zeng,Asta Försti,Bowang Chen,Stefano Landi,Andre Franke,Annegret Fischer,David Ellinghaus,Carlos Flores,Imre Noth,Shwu-Fan Ma,Jia Nee Foo,Jianjun Liu,Jong-Won Kim,David G. Cox,Olivier Delattre,Olivier Mirabeau,Christine F. Skibola,Clara S. Tang,Merce Garcia-Barcelo,Kai-Ping Chang,Wen-Hui Su,Yu-Sun Chang,Nicholas G. Martin,Scott D. Gordon,Tracey D. Wade,Chaeyoung Lee,Michiaki Kubo,Pei-Chieng Cha,Yusuke Nakamura,Daniel Levy,Masayuki Kimura,Shih-Jen Hwang,Steven C. Hunt,Tim D. Spector,Nicole Soranzo,Ani Manichaikul,R. Graham Barr,Bratati Kahali,Elizabeth K. Speliotes,Laura M. Yerges-Armstrong,Ching-Yu Cheng,Jost B. Jonas,Tien Yin Wong,Isabella Fogh,Kuang Lin,John Powell,Kenneth Rice,Caroline L Relton,Richard M. Martin,George Davey Smith +197 more
TL;DR: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases, as well as single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population.
Journal ArticleDOI
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex
Yutaka Shimomura,Dritan Agalliu,Alin Vonica,Victor Luria,Muhammad Wajid,Alessandra Baumer,Serena Belli,Lynn Petukhova,Albert Schinzel,Ali H. Brivanlou,Ben A. Barres,Angela M. Christiano +11 more
TL;DR: It is shown that APCDD1 is a membrane-bound glycoprotein that is abundantly expressed in human hair follicles, and can interact in vitro with WNT3A and LRP5—two essential components of Wnt signalling.
Journal ArticleDOI
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci
Regina C. Betz,Lynn Petukhova,Stephan Ripke,Stephan Ripke,Hailiang Huang,Hailiang Huang,Androniki Menelaou,Silke Redler,Tim Becker,Tim Becker,Stefanie Heilmann,Tarek Yamany,Madeliene Duvic,Maria K. Hordinsky,David A. Norris,Vera H. Price,Julian Mackay-Wiggan,Annemieke de Jong,Gina M. DeStefano,Susanne Moebus,Markus Böhm,Ulrike Blume-Peytavi,Hans Wolff,Gerhard Lutz,Roland Kruse,Li Bian,Christopher I. Amos,Annette Lee,Peter K. Gregersen,Bettina Blaumeiser,David Altshuler,David Altshuler,Raphael Clynes,Paul I.W. de Bakker,Markus M. Nöthen,Mark J. Daly,Mark J. Daly,Angela M. Christiano +37 more
TL;DR: The first meta-analysis in AA is performed by combining data from two genome-wide association studies (GWAS), and replication with supplemented ImmunoChip data for a total of 3,253 cases and 7,543 controls, finding new molecular pathways disrupted in AA that support the causal role of aberrant immune processes in AA.