C
Chao Xing
Researcher at University of Texas Southwestern Medical Center
Publications - 206
Citations - 11484
Chao Xing is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 38, co-authored 169 publications receiving 8895 citations. Previous affiliations of Chao Xing include Case Western Reserve University & Bristol-Myers Squibb.
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Journal ArticleDOI
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
Stefano Romeo,Julia Kozlitina,Julia Kozlitina,Chao Xing,Alexander Pertsemlidis,David Cox,Len A. Pennacchio,Len A. Pennacchio,Eric Boerwinkle,Jonathan C. Cohen,Helen H. Hobbs +10 more
TL;DR: Variation in PNPLA3 contributes to ancestry-related and inter-individual differences in hepatic fat content and susceptibility to NAFLD.
Journal ArticleDOI
Adult-onset pulmonary fibrosis caused by mutations in telomerase
Kalliopi D. Tsakiri,Jennifer T. Cronkhite,Phillip J. Kuan,Chao Xing,Ganesh Raghu,Jonathan C. Weissler,Randall L. Rosenblatt,Jerry W. Shay,Christine Kim Garcia +8 more
TL;DR: Linkage to map the disease gene in two families to chromosome 5 revealed mutations in TERT or TERC that result in telomere shortening over time confer a dramatic increase in susceptibility to adult-onset IPF.
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Hypoxia induces heart regeneration in adult mice
Yuji Nakada,Diana C. Canseco,Suwannee Thet,Salim Abdisalaam,Aroumougame Asaithamby,Celio X.C. Santos,Ajay M. Shah,Hua Zhang,James E. Faber,Michael Kinter,Luke I. Szweda,Chao Xing,Zeping Hu,Ralph J. DeBerardinis,Gabriele G. Schiattarella,Joseph A. Hill,Orhan K. Öz,Zhigang Lu,Cheng Cheng Zhang,Wataru Kimura,Wataru Kimura,Hesham A. Sadek +21 more
TL;DR: It is demonstrated that the endogenous regenerative properties of the adult mammalian heart can be reactivated by exposure to gradual systemic hypoxaemia, and the potential therapeutic role of hypoxia in regenerative medicine is highlighted.
Journal ArticleDOI
Telomere shortening in familial and sporadic pulmonary fibrosis
Jennifer T. Cronkhite,Chao Xing,Ganesh Raghu,Kelly Chin,Fernando Torres,Randall L. Rosenblatt,Christine Kim Garcia +6 more
TL;DR: A significant fraction of individuals with pulmonary fibrosis have short telomere lengths that cannot be explained by coding mutations in telomerase, which may be a marker for an increased predisposition toward the development of this age-associated disease.
Journal ArticleDOI
Genetic Defects in Surfactant Protein A2 Are Associated with Pulmonary Fibrosis and Lung Cancer
Yongyu Wang,Phillip J. Kuan,Chao Xing,Jennifer T. Cronkhite,Fernando Torres,Randall L. Rosenblatt,J. Michael DiMaio,Lisa N. Kinch,Nick V. Grishin,Christine Kim Garcia +9 more
TL;DR: A rare missense mutation in a candidate gene, SFTPA2, within the interval encoding surfactant protein A2 (SP-A2) was identified and another rare mutation in S FTPA2 was identified in another family with IPF and lung cancer.