C
Charles Boone
Researcher at University of Toronto
Publications - 314
Citations - 46014
Charles Boone is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Synthetic genetic array. The author has an hindex of 100, co-authored 294 publications receiving 42217 citations. Previous affiliations of Charles Boone include Canadian Institute for Advanced Research & Queen's University.
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Identification of Saccharomyces cerevisiae spindle pole body remodeling factors.
TL;DR: NUP60, POM152, and NCS2 are required for SPB growth during a mitotic cell cycle arrest, and UBC4 is required to maintain SPB size during the cell cycle.
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PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae.
Ke Jin,Jingjing Li,Frederick S. Vizeacoumar,Zhijian Li,Renqiang Min,Lee Zamparo,Franco J. Vizeacoumar,Alessandro Datti,Brenda J. Andrews,Charles Boone,Zhaolei Zhang +10 more
TL;DR: The design and implementation of an online database, PhenoM (Phenomics of yeast Mutants), for storing, retrieving, visualizing and data mining the quantitative single-cell measurements extracted from micrographs of the ts mutant cells is described.
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Global Linkage Map Connects Meiotic Centromere Function to Chromosome Size in Budding Yeast
Anastasia Baryshnikova,Benjamin VanderSluis,Michael Costanzo,Chad L. Myers,Rita S. Cha,Brenda J. Andrews,Charles Boone +6 more
TL;DR: Synthetic genetic array analysis automates yeast genetics, enabling high-throughput construction of ordered arrays of double mutants, and results suggest that chromosome size may have a direct role in regulating the fidelity of chromosome segregation during meiosis.
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The indispensable genome
Charles Boone,Brenda J. Andrews +1 more
TL;DR: For the first time, the authors now have a firm handle on the core set of essential genes that are required for human cell division, which opens the door to studying the roles ofessential genes, how gene essentiality depends on genetic and tissue contexts, and how essential genes evolve.
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Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae .
Jessica R. Eisenstatt,Lars Boeckmann,Wei-Chun Au,Valerie Garcia,Levi Bursch,Josefina Ocampo,Michael Costanzo,Michael Weinreich,Robert A. Sclafani,Anastasia Baryshnikova,Chad L. Myers,Charles Boone,David Clark,Richard Baker,Munira A. Basrai +14 more
TL;DR: A DNA replication initiation-independent role of DDK as a regulator of Psh1-mediated proteolysis of Cse4 to prevent mislocalization of CenP-A is defined.