C
Charles Boone
Researcher at University of Toronto
Publications - 314
Citations - 46014
Charles Boone is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Synthetic genetic array. The author has an hindex of 100, co-authored 294 publications receiving 42217 citations. Previous affiliations of Charles Boone include Canadian Institute for Advanced Research & Queen's University.
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The Saccharomyces cerevisiae homolog of p24 is essential for maintaining the association of p150Glued with the dynactin complex.
TL;DR: The genetic interaction of ldb18Δ with stu1-5 also supports the notion that dynein/dynactin helps to generate a spindle pole separating force, and is synthetic lethal with mutations affecting the Kar9 spindle orientation pathway.
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Identification of RCN1 and RSA3 as ethanol‐tolerant genes in Saccharomyces cerevisiae using a high copy barcoded library
TL;DR: It is concluded that regulation of ribosome biogenesis and ultimately translation is a critical factor for S. cerevisiae survival during industrial-related environmental stress.
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Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae
Dimitris Kyriakou,Emmanouil Stavrou,Panayiota Demosthenous,Georgia Angelidou,Bryan-Joseph San Luis,Charles Boone,Vasilis J. Promponas,Antonis Kirmizis +7 more
TL;DR: This work consistently demonstrates that SUT457 is required for telomeric overhang homeostasis through an Exo1-dependent pathway and proposes that systematic application of this genetic approach could determine the functional significance of individual lncRNAs in yeast and other complex organisms.
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Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets.
Ci Fu,Xiang Zhang,Amanda O. Veri,Kali R. Iyer,Emma Lash,Alice Xue,Huijuan Yan,Nicole M. Revie,Cassandra J. Wong,Zhen-Yuan Lin,Elizabeth J. Polvi,Sean D Liston,Benjamin VanderSluis,Jing Hou,Yoko Yashiroda,Anne-Claude Gingras,Anne-Claude Gingras,Charles Boone,Teresa R. O’Meara,Matthew J. O’Meara,Suzanne M. Noble,Nicole Robbins,Chad L. Myers,Leah E. Cowen +23 more
TL;DR: In this paper, a machine learning model was used to generate genome-wide gene essentiality predictions for C. albicans and expand the largest functional genomics resource in this pathogen (the GRACE collection) by 866 genes.
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Ybp2 Associates with the Central Kinetochore of Saccharomyces cerevisiae and Mediates Proper Mitotic Progression
TL;DR: Ybp2 seems to be part of a macromolecular kinetochore complex and appears to contribute to the proper associations among the central kinetchore subcomplexes and the kinet Cochore-specific nucleosome.