Charles Boone

TL;DR: It is shown that ABC transporters physically associate with proteins involved in a surprisingly diverse range of functions, and the importance of the physical interactions of ABCtransporters in both the regulation of one another and in the modulation of proteinsinvolved in zinc homeostasis is examined.

TL;DR: The direct discovery of disease genes and variants in humans has been revolutionized, first by genome-wide association studies and now by whole-genome sequencing, and it is now much easier to directly identify potential disease genes in humans.

TL;DR: A data mining approach was developed to exhaustively discover all block structures within Saccharomyces cerevisiae's genetic interaction network, which allowed for its complete modular decomposition and revealed the importance of the context of individual genetic interactions in their interpretation and revealed distinct trends among genetic interaction hubs.

TL;DR: The discovery of poacic acid as a natural antifungal agent targeting β-1,3-glucan highlights the potential side use of products generated in the processing of renewable biomass toward biofuels as a source of valuable bioactive compounds and further clarifies the nature and mechanism of fermentation inhibitors found in lignocellulosic hydrolysates.

TL;DR: This study provides a valuable resource to unravel novel functional relationships and pathways regulated by kinases and outlines a general strategy for deciphering mutant phenotypes from large-scale GI networks.