C
Charles Boone
Researcher at University of Toronto
Publications - 314
Citations - 46014
Charles Boone is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Synthetic genetic array. The author has an hindex of 100, co-authored 294 publications receiving 42217 citations. Previous affiliations of Charles Boone include Canadian Institute for Advanced Research & Queen's University.
Papers
More filters
Journal ArticleDOI
Global Genetic Networks and the Genotype-to-Phenotype Relationship
Michael Costanzo,Elena Kuzmin,Jolanda van Leeuwen,Barbara Mair,Jason Moffat,Charles Boone,Brenda J. Andrews +6 more
TL;DR: It is emphasized how information gained from work in yeast translates to other systems, and how a global genetic network not only annotates gene function but also provides new insights into the genotype-to-phenotype relationship.
Journal ArticleDOI
Exploring genetic suppression interactions on a global scale
Jolanda van Leeuwen,Carles Pons,Joseph C. Mellor,Joseph C. Mellor,Takafumi N. Yamaguchi,Takafumi N. Yamaguchi,Helena Friesen,John H. Koschwanez,Mojca Mattiazzi Usaj,Maria Pechlaner,Mehmet Takar,Matej Usaj,Benjamin VanderSluis,Kerry Andrusiak,Pritpal Bansal,Pritpal Bansal,Anastasia Baryshnikova,Claire E. Boone,Jessica Cao,Atina G. Cote,Atina G. Cote,Marinella Gebbia,Marinella Gebbia,Gene Horecka,Ira Horecka,Elena Kuzmin,Nicole Legro,Wendy Liang,Natascha van Lieshout,Natascha van Lieshout,Margaret McNee,Bryan-Joseph San Luis,Fatemeh Shaeri,Fatemeh Shaeri,Ermira Shuteriqi,Song Sun,Lu Yang,Ji-Young Youn,Michael Yuen,Michael Costanzo,Anne-Claude Gingras,Anne-Claude Gingras,Patrick Aloy,Chris Oostenbrink,Andrew W. Murray,Todd R. Graham,Chad L. Myers,Chad L. Myers,Brenda J. Andrews,Frederick P. Roth,Charles Boone,Charles Boone +51 more
TL;DR: A large-scale study in yeast reveals how defects associated with a mutation in one gene can be compensated for by a second mutation in a suppressor gene, and assembled a global network of genetic suppression interactions, which highlights the major potential for systematic studies of suppression to map cellular function.
Journal ArticleDOI
Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae.
James B. Anderson,Caroline Sirjusingh,Ainslie B. Parsons,Charles Boone,Claire Wickens,Leah E. Cowen,Linda M. Kohn +6 more
TL;DR: It is shown that mode of selection, degree of dominance of mutations, and ploidy are determining factors in the evolution of resistance to the antifungal drug fluconazole in yeast.
Journal ArticleDOI
Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation
Vivien Measday,Kristin Baetz,Julie Guzzo,Karen Yuen,Teresa Kwok,Bilal N. Sheikh,Huiming Ding,Ryo Ueta,Trinh Hoac,Benjamin Cheng,Isabelle Pot,Amy Hin Yan Tong,Yuko Yamaguchi-Iwai,Charles Boone,Phil Hieter,Brenda J. Andrews +15 more
TL;DR: This study shows that systematic genetic screens are a powerful means to discover roles for uncharacterized genes and genes with alternative functions in chromosome maintenance that may not be discovered by using proteomics approaches.
Journal ArticleDOI
Bringing order to protein disorder through comparative genomics and genetic interactions
Jeremy Bellay,Sangjo Han,Magali Michaut,TaeHyung Kim,Michael Costanzo,Brenda J. Andrews,Charles Boone,Gary D. Bader,Chad L. Myers,Philip M. Kim +9 more
TL;DR: The clear and distinct functional association of flexible and constrained disorder will allow for new approaches and more specific algorithms for disorder detection in a functional context and demonstrate clear evolutionary selection of protein disorder with little selection on primary structure.