C
Charles Boone
Researcher at University of Toronto
Publications - 314
Citations - 46014
Charles Boone is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Synthetic genetic array. The author has an hindex of 100, co-authored 294 publications receiving 42217 citations. Previous affiliations of Charles Boone include Canadian Institute for Advanced Research & Queen's University.
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Journal ArticleDOI
Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping
Kamran Rizzolo,Jennifer Huen,Ashwani Kumar,Sadhna Phanse,Sadhna Phanse,James Vlasblom,Yoshito Kakihara,Hussein A. Zeineddine,Zoran Minic,Jamie Snider,Wen Wang,Carles Pons,Thiago V. Seraphim,Thiago V. Seraphim,Edgar E. Boczek,Simon Alberti,Michael Costanzo,Chad L. Myers,Igor Stagljar,Charles Boone,Mohan Babu,Walid A. Houry +21 more
TL;DR: An expanded view of the chaperone network in the cell clearly demonstrates the distinction between chaperones having broad versus narrow substrate specificities in protein homeostasis.
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Retention of duplicated genes in evolution.
TL;DR: The processes that lead to the retention of duplicated genes are not well understood as mentioned in this paper, but functional genomics approaches in model organisms, such as yeast, provide useful tools to test the mechanisms underlying retention with functional redundancy and divergence.
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Inorganic Phosphate Deprivation Causes tRNA Nuclear Accumulation via Retrograde Transport in Saccharomyces cerevisiae
TL;DR: It is revealed that inorganic phosphate deprivation causes transient, temperature-dependent nuclear accumulation of mature cytoplasmic tRNA within nuclei via a Mtr10- and retrograde-dependent pathway, providing a novel connection between tRNA subcellular dynamics and phosphate availability.
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Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity
Can Kayatekin,Audra L. Amasino,Giorgio Gaglia,Jason Flannick,Jason Flannick,Julia Maeve Bonner,Saranna Fanning,Priyanka Narayan,M. Inmaculada Barrasa,David Pincus,Dirk Landgraf,Justin Nelson,William R. Hesse,Michael Costanzo,Chad L. Myers,Charles Boone,Jose C. Florez,Susan Lindquist,Susan Lindquist +18 more
TL;DR: Ste24, an evolutionarily conserved protease that was recently reported to degrade peptides stuck within the translocon between the cytoplasm and the endoplasmic reticulum, was the strongest suppressor of IAPP toxicity.
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Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.
Lisa Yu,Andres Lopez,Abderrahmane Anaflous,Brahim El Bali,Abdellah Hamal,Elke Ericson,Lawrence E. Heisler,Angus McQuibban,Guri Giaever,Corey Nislow,Charles Boone,Grant W. Brown,Mohammed Bellaoui +12 more
TL;DR: In this paper, the authors used validated chemogenomic assays in Saccharomyces cerevisiae, and discovered that two closely related compounds, an imidazo[1,2-a]pyridine and -pyrimidine that differ by a single atom, have distinctly different mechanisms of action.