C
Charles Boone
Researcher at University of Toronto
Publications - 314
Citations - 46014
Charles Boone is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Synthetic genetic array. The author has an hindex of 100, co-authored 294 publications receiving 42217 citations. Previous affiliations of Charles Boone include Canadian Institute for Advanced Research & Queen's University.
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Journal ArticleDOI
Role of Yeast Insulin-Degrading Enzyme Homologs in Propheromone Processing and Bud Site Selection
TL;DR: The Saccharomyces cerevisiae AXL1 gene product Axl1p has been shown to participate in the dual regulation of distinct signaling pathways, and a member of the insulinase family has been implicated in propeptide processing.
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The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast
Gabriel Musso,Michael Costanzo,ManQin Huangfu,Andrew M. Smith,Jadine Paw,Bryan-Joseph San Luis,Charles Boone,Guri Giaever,Corey Nislow,Andrew Emili,Zhaolei Zhang +10 more
TL;DR: It is found that more than one-third (140) of the 399 examinable WGD paralog pairs were epistatic under standard laboratory conditions and that additional cases of epistasis became obvious only under media conditions designed to induce cellular stress, suggesting that many epistatic relationships remain unresolved.
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The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways
Neal M. Alto,Andrew W. Weflen,Matthew J. Rardin,Defne Yarar,Cheri S. Lazar,Raffi Tonikian,Antonius Koller,Susan S. Taylor,Charles Boone,Sachdev S. Sidhu,Sandra L. Schmid,Gail Hecht,Jack E. Dixon +12 more
TL;DR: It is demonstrated that the enteropathogenic Escherichia coli (EPEC) type III effector protein EspF nucleates a multiprotein signaling complex composed of eukaryotic sorting nexin 9 (SNX9) and neuronal Wiskott-Aldrich syndrome protein (N-WASP).
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Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pHc in Saccharomyces cerevisiae
Rick Orij,Malene L. Urbanus,Franco J. Vizeacoumar,Guri Giaever,Charles Boone,Corey Nislow,Stanley Brul,Gertien J. Smits +7 more
TL;DR: In the model organism yeast, pHc changes in response to the presence of nutrients and varies during growth, which can lead to major changes in metabolism, signal transduction, and phenotype.
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The Src homology domain 3 (SH3) of a yeast type I myosin, Myo5p, binds to verprolin and is required for targeting to sites of actin polarization.
Blake L. Anderson,Istvan R. Boldogh,Marie Evangelista,Charles Boone,Lloyd A. Greene,Liza A. Pon +5 more
TL;DR: The studies support a multistep model for Myo5p targeting in yeast and find that latrunculin-A–induced depolymerization of F-actin results in loss of Myi5p patches, and contributes to but is not sufficient for localization of Myo 5p either to patches or to sites of polarized cell growth.