Charles Boone

TL;DR: This work constructed a genome-wide set of targeted deletion alleles and introduced them into a filamentous S. cerevisiae strain and identified genes involved in morphologically distinct forms of filamentation: haploid invasive growth, biofilm formation, and diploid pseudohyphal growth.

TL;DR: An integrated Saccharomyces cerevisiae interaction network is assembled in which nodes represent genes (or their protein products) and differently colored links represent the aforementioned five biological interaction types and it is shown that most of the motifs form 'network themes' – classes of higher-order recurring interconnection patterns that encompass multiple occurrences of network motifs.

TL;DR: A generic strategy for identifying genes and pathways induced by individual TFs that does not require knowledge of their normal activation cues is described, presenting a straightforward approach to discovery of TF activities and mapping targets that could be adapted to any organism with transgenic technology.

TL;DR: A conserved yeast network (CYN) is defined composed of 106 genes and 144 interactions and it is suggested that this network may help understand the shared biology of diverse eukaryotic species.

TL;DR: A genome-scale specificity and interaction map for yeast SH3 domain-containing proteins reveal how family members show selective binding to target proteins and predicts the dynamic localization of new candidate endocytosis proteins.