C
Charles Boone
Researcher at University of Toronto
Publications - 314
Citations - 46014
Charles Boone is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Synthetic genetic array. The author has an hindex of 100, co-authored 294 publications receiving 42217 citations. Previous affiliations of Charles Boone include Canadian Institute for Advanced Research & Queen's University.
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Formins: signaling effectors for assembly and polarization of actin filaments
TL;DR: Bni1p, which is a member of the formin family of proteins, has been shown to nucleate actin filaments in vitro and binds profilin, an actin-monomer-binding protein that delivers actin to the growing barbed end of filaments.
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A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.
TL;DR: A systematic screen of the set of viable Saccharomyces cerevisiae haploid gene deletion mutants is performed and 103 genes whose deletion causes sensitivity to the DNA-damaging agent methyl methanesulfonate are identified, including a subset of genes that show a specific MMS response.
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Systematic mapping of genetic interaction networks.
TL;DR: Techniques enabling systematic genetic interaction mapping have been extended to other single-celled organisms, the bacteria Escherichia coli and the yeast Schizosaccharomyces pombe, opening the way to comparative investigations of interaction networks.
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Systematic Exploration of Synergistic Drug Pairs
Murat Cokol,Murat Cokol,Hon Nian Chua,Hon Nian Chua,Murat Tasan,Murat Tasan,Beste Mutlu,Zohar B. Weinstein,Yo Suzuki,Yo Suzuki,Mehmet Ercan Nergiz,Michael Costanzo,Anastasia Baryshnikova,Guri Giaever,Corey Nislow,Chad L. Myers,Brenda J. Andrews,Charles Boone,Frederick P. Roth +18 more
TL;DR: The majority of drug synergies appear to result from non‐specific promiscuous synergy, and the promiscuity of Tacrolimus and Pentamidine was completely unexpected.
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A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.
Cheuk Hei Ho,Leslie Magtanong,Sarah L. Barker,David Gresham,Shinichi Nishimura,Paramasivam Natarajan,Judice L. Y. Koh,Justin Porter,Christopher A. Gray,Raymond J. Andersen,Guri Giaever,Corey Nislow,Brenda J. Andrews,David Botstein,Todd R. Graham,Minoru Yoshida,Charles Boone +16 more
TL;DR: A yeast chemical-genomics approach designed to identify genes that when mutated confer drug resistance, thereby providing insight about the modes of action of compounds is presented, and a new class of sterol-binding compounds is discovered.