C
Charles Boone
Researcher at University of Toronto
Publications - 314
Citations - 46014
Charles Boone is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Synthetic genetic array. The author has an hindex of 100, co-authored 294 publications receiving 42217 citations. Previous affiliations of Charles Boone include Canadian Institute for Advanced Research & Queen's University.
Papers
More filters
Journal ArticleDOI
Reduced gene dosage of histone H4 prevents CENP-A mislocalization and chromosomal instability in Saccharomyces cerevisiae.
Jessica R. Eisenstatt,Kentaro Ohkuni,Wei-Chun Au,Olivia Preston,Loran Gliford,Evelyn Suva,Michael Costanzo,Charles Boone,Munira A. Basrai +8 more
TL;DR: In this paper, the authors used a genome-wide screen to identify factors that facilitate the mislocalization of overexpressed Cse4 by characterizing suppressors of the psh1Δ GALCSE4 SDL.
Journal ArticleDOI
High-Throughput Microscopy-Based Screening in Saccharomyces cerevisiae
TL;DR: An introduction to automated imaging in budding yeast is provided to overcome issues associated with manual image analysis and acquire unbiased, quantitative data.
Posted ContentDOI
Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interaction networks
Scott W. Simpkins,Justin Nelson,Raamesh Deshpande,Sheena C. Li,Jeff S. Piotrowski,Erin H. Wilson,Abraham A Gebre,Reika Okamoto,Mami Yoshimura,Michael Costanzo,Yoko Yashiroda,Yoshikazu Ohya,Hiroyuki Osada,Minoru Yoshida,Charles Boone,Chad L. Myers +15 more
TL;DR: The proposed CG-TARGET method integrates large-scale chemical-genetic interaction screening data with a genetic interaction network to predict the biological processes perturbed by compounds, and demonstrates the use of genetic interaction networks in the functional annotation of compounds to biological processes.
Journal ArticleDOI
Beyond the genome: from genomics to systems biology.
Philippe Glaser,Charles Boone +1 more
Journal ArticleDOI
Problems with co-funding in Canada.
Mike Tyers,Eric D. Brown,David W. Andrews,J. M. John Bergeron,Charles Boone,Roderick Bremner,Howard Bussey,James C. Cross,Julian Davies,Michel Desjardins,John E. Dick,Daniel J. Dumont,Daniel Durocher,Michael J. Ellison,G. Brian Golding,Michael W. Gray,Lea Harrington,Philip Hieter,Geral d Johnston,David J. Kelvin,Brian E. McCarry,Stephen W. Michnick,Francis Ouellette,Ron E. Pearlman,Linda Z. Penn,Jerry Pelletier,Richard A. Rachubinski,Paul S. Rennie,Daniel a Rotin,Robert Rottapel,Ivan Sadowski,Frank Sicheri,Lou Siminovitch,Nahum Sonenberg,K. W. Michael Siu,Michel L. Tremblay,Neil Winegarden,Richard W. Wozniak,Gerard D. Wright,James R. Woodgett +39 more
TL;DR: The Canadian Federal Government has prudently invested substantial new resources in research operations and infrastructure, thereby bringing the level of research support in Canada on par with that of most other G8 countries and enabling a world-class research enterprise.