The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids
Cholsoon Jang,Sheng Hui,Wenyun Lu,Alexis J. Cowan,Raphael J. Morscher,Gina Lee,Wei Liu,Gregory J. Tesz,Morris J. Birnbaum,Joshua D. Rabinowitz +9 more
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TLDR
It is proposed that the small intestine shields the liver from otherwise toxic fructose exposure, finding that dietary fructose is cleared by theSmall intestine, both by prior exposure to fructose and by feeding.About:
This article is published in Cell Metabolism.The article was published on 2018-02-06 and is currently open access. It has received 380 citations till now. The article focuses on the topics: Fructose.read more
Citations
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Mechanisms of NAFLD development and therapeutic strategies
TL;DR: Understanding of pathogenic mechanisms and clinical features of NAFLD is driving progress in therapeutic strategies now in clinical trials and the emerging targets for drug development that involve either single agents or combination therapies intended to arrest or reverse disease progression are discussed.
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Diet-Independent Correlations between Bacteria and Dysfunction of Gut, Adipose Tissue, and Liver: A Comprehensive Microbiota Analysis in Feces and Mucosa of the Ileum and Colon in Obese Mice with NAFLD.
Eveline Gart,Everton Souto Lima,Frank H. J. Schuren,Christa de Ruiter,Joline Attema,Lars Verschuren,Jaap Keijer,Kanita Salic,Martine C. Morrison,Robert Kleemann +9 more
TL;DR: A first systematic analysis of microbiota changes in the ileum and colon using multiple diets and investigating both fecal and mucosal samples demonstrates correlations between the microbiota and dysfunctions of gut, adipose tissue, and liver, independent of a specific disease-inducing diet.
Journal ArticleDOI
Molecular and cellular mechanisms of liver fibrosis and its regression.
TL;DR: This Review summarizes studies of the molecular mechanisms underlying the reversibility of liver fibrosis, including apoptosis and the inactivation of hepatic stellate cells, the crosstalk between the liver and the systems that orchestrate the recruitment of bone marrow-derived macrophages driving fibrosis resolution, and the interactions between various cell types that lead to the intracellular signalling that induces fibrosis or its regression.
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The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease
TL;DR: It is argued that the Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome, and by studying how ultra-processing changes the properties of whole foods and how these foods affect the gut microbiome, more useful dietary guidelines can be made.
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Gut microbial metabolites as multi-kingdom intermediates
TL;DR: The major classes of microbial metabolites are discussed, examples of how microbial metabolites affect host health are highlighted and a potential framework for integration of discovery-based metabolite studies with mechanistic work is provided.
References
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Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity.
TL;DR: The increase in consumption of HFCS has a temporal relation to the epidemic of obesity, and the overconsumption of H FCS in calorically sweetened beverages may play a role in the epidemic.
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Metabolic Effects of Fructose and the Worldwide Increase in Obesity
Luc Tappy,Kim-Anne Lê +1 more
TL;DR: Although there is compelling evidence that very high fructose intake can have deleterious metabolic effects in humans as in rodents, the role of fructose in the development of the current epidemic of metabolic disorders remains controversial.
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Eine einfache Technik der extrem schnellen Abkühlung größerer Gewebestücke
TL;DR: In this article, a pair of tongs are used to compress large tissue pieces and organs of animals to a thin layer and can thus be frozen in a fraction of a second.
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Sugar, Uric Acid, and the Etiology of Diabetes and Obesity
Richard J. Johnson,Richard J. Johnson,Takahiko Nakagawa,Takahiko Nakagawa,L. Gabriela Sánchez-Lozada,Mohamed Shafiu,Shikha S. Sundaram,MyPhuong T. Le,Takuji Ishimoto,Yuri Y. Sautin,Miguel A. Lanaspa +10 more
TL;DR: The hypothesis that fructose-mediated generation of uric acid may have a causal role in diabetes and obesity is revisited and new insights into pathogenesis and therapies for this important disease are provided.
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Metabolomic analysis and visualization engine for LC-MS data.
TL;DR: A software package designed for efficient interactive analysis of LC-MS data, including in the presence of isotope labeling, that contains tools for all aspects of the data analysis process, from feature extraction to pathway-based graphical data display.
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