E
Eran A. Mukamel
Researcher at University of California, San Diego
Publications - 74
Citations - 8852
Eran A. Mukamel is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Epigenomics & DNA methylation. The author has an hindex of 30, co-authored 66 publications receiving 6684 citations. Previous affiliations of Eran A. Mukamel include University of California & University of California, Los Angeles.
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Journal ArticleDOI
Global Epigenomic Reconfiguration During Mammalian Brain Development
Ryan Lister,Ryan Lister,Eran A. Mukamel,Joseph R. Nery,Mark A. Urich,Clare A. Puddifoot,Nicholas D. Johnson,Jacinta Lucero,Yun Huang,Andrew J. Dwork,Matthew D. Schultz,Matthew D. Schultz,Miao Yu,Julian Tonti-Filippini,Holger Heyn,Shijun Hu,Joseph C. Wu,Anjana Rao,Manel Esteller,Chuan He,Fatemeh Haghighi,Terrence J. Sejnowski,Terrence J. Sejnowski,M. Margarita Behrens,Joseph R. Ecker +24 more
TL;DR: The results extend the knowledge of the unique role of DNA methylation in brain development and function, and offer a new framework for testing the role of the epigenome in healthy function and in pathological disruptions of neural circuits.
Journal ArticleDOI
Automated analysis of cellular signals from large-scale calcium imaging data
TL;DR: An automated sorting procedure is described that combines independent component analysis and image segmentation for extracting cells' locations and their dynamics with minimal human supervision and found microzones of Purkinje cells that were stable across behavioral states and in which synchronous Ca(2+) spiking rose significantly during locomotion.
Journal ArticleDOI
Electroencephalogram signatures of loss and recovery of consciousness from propofol
Patrick L. Purdon,Eric T. Pierce,Eran A. Mukamel,Eran A. Mukamel,Michael J. Prerau,John L. Walsh,Kin Foon Kevin Wong,Andres F. Salazar-Gomez,Priscilla G. Harrell,Aaron L. Sampson,Aylin Cimenser,ShiNung Ching,Nancy Kopell,Casie Tavares-Stoeckel,Kathleen Habeeb,Rebecca C. Merhar,Emery N. Brown +16 more
TL;DR: This work found specific behavioral and electrophysiological changes that mark the transition between consciousness and unconsciousness induced by propofol, one of the most commonly used anesthetic drugs.
Journal ArticleDOI
Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain
Alisa Mo,Eran A. Mukamel,Eran A. Mukamel,Fred P. Davis,Chongyuan Luo,Gilbert L. Henry,Serge Picard,Mark A. Urich,Joseph R. Nery,Terrence J. Sejnowski,Terrence J. Sejnowski,Ryan Lister,Ryan Lister,Sean R. Eddy,Joseph R. Ecker,Jeremy Nathans +15 more
TL;DR: The first affinity purification approach to isolate nuclei from genetically defined cell types in a mammal is developed and this technique is combined with next-generation sequencing to show that three subtypes of neocortical neurons have highly distinctive epigenomic landscapes.
Journal ArticleDOI
Human body epigenome maps reveal noncanonical DNA methylation variation
Matthew D. Schultz,Yupeng He,John W. Whitaker,Manoj Hariharan,Eran A. Mukamel,Danny Leung,Nisha Rajagopal,Joseph R. Nery,Mark A. Urich,Huaming Chen,Shin Lin,Yiing Lin,Inkyung Jung,Anthony D. Schmitt,Siddarth Selvaraj,Bing Ren,Terrence J. Sejnowski,Wei Wang,Joseph R. Ecker +18 more
TL;DR: High coverage methylomes are reported that catalogue cytosine methylation in all contexts for the major human organ systems, integrated with matched transcriptomes and genomic sequence.