Hannah R Elliott

TL;DR: At least one in 200 healthy humans harbors a pathogenic mtDNA mutation that potentially causes disease in the offspring of female carriers, and the exclusive detection of m.14484T→C on haplogroup J implicates the background mtDNA haplotype in mutagenesis.

TL;DR: A nested case-control study of DNA methylation in Indian Asians and Europeans with incident type 2 diabetes who were identified from the 8-year follow-up of 25 372 participants in the London Life Sciences Prospective Population study.

TL;DR: The smoking score is a valuable tool for identification of true current smoking behaviour and Explanations for ethnic differences in DNA methylation in association with smoking may provide valuable clues to disease pathways.

TL;DR: MicroRNA-455 is expressed during chondrogenesis and in adult articular cartilage, where it can regulate TGFβ signaling, suppressing the Smad2/3 pathway and contributing to disease pathology.

TL;DR: There is an emerging evidence that mitochondria contain the machinery required to epigenetically modify mtDNA expression, which could lead to the epigenetic modification of the nuclear genome, including chromatin remodelling and alterations to DNA methylation and microRNA expression, thus contributing to the diverse pathophysiology observed in this group of diseases.