C
Chris Janetopoulos
Researcher at University of the Sciences
Publications - 52
Citations - 4383
Chris Janetopoulos is an academic researcher from University of the Sciences. The author has contributed to research in topics: Dictyostelium discoideum & Heterotrimeric G protein. The author has an hindex of 19, co-authored 48 publications receiving 3912 citations. Previous affiliations of Chris Janetopoulos include Johns Hopkins University School of Medicine & Johns Hopkins University.
Papers
More filters
Journal ArticleDOI
Lattice Light Sheet Microscopy: Imaging Molecules to Embryos at High Spatiotemporal Resolution
Bi-Chang Chen,Wesley R. Legant,Kai Wang,Lin Shao,Daniel E. Milkie,Michael W. Davidson,Chris Janetopoulos,Xufeng S. Wu,John A. Hammer,Zhe Liu,Brian P. English,Yuko Mimori-Kiyosue,Daniel P. Romero,Alex T. Ritter,Alex T. Ritter,Jennifer Lippincott-Schwartz,Lillian K. Fritz-Laylin,R. Dyche Mullins,Diana M. Mitchell,Joshua N. Bembenek,Anne-Cécile Reymann,Ralph Böhme,Stephan W. Grill,Jennifer T. Wang,Geraldine Seydoux,U. Serdar Tulu,Daniel P. Kiehart,Eric Betzig +27 more
TL;DR: A new microscope using ultrathin light sheets derived from two-dimensional optical lattices is developed, demonstrating the performance advantages of lattice light-sheet microscopy compared with previous techniques and highlighted phenomena that, when seen at increased spatiotemporal detail, may hint at previously unknown biological mechanisms.
Journal ArticleDOI
Receptor-Mediated Activation of Heterotrimeric G-Proteins in Living Cells
TL;DR: Construction of similar energy-transfer pairs of mammalian G-proteins should enable direct in situ mechanistic studies and applications such as drug screening and identifying ligands of newly found G-protein–coupled receptors.
Journal ArticleDOI
Eukaryotic chemotaxis: distinctions between directional sensing and polarization.
TL;DR: A local excitation-global inhibition model can account for the localization of PI3K and PTEN and thereby explain directional sensing, however, elements of other models, including positive feedback and the reaction of the cytoskeleton, must be invoked to account for polarization.
Journal ArticleDOI
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton
TL;DR: Combinations of temporal and spatial stimuli provided evidence of an inhibitory process and showed that a gradient generates a persistent steady-state response independent of a previous history of exposure to chemoattractant.
Journal ArticleDOI
G protein–independent Ras/PI3K/F-actin circuit regulates basic cell motility
Atsuo T. Sasaki,Chris Janetopoulos,Chris Janetopoulos,Susan Lee,Pascale G. Charest,Kosuke Takeda,Lauren W. Sundheimer,Ruedi Meili,Peter N. Devreotes,Richard A. Firtel +9 more
TL;DR: Simultaneous imaging analysis reveals that in the absence of extracellular stimuli, autonomous PI3K and Ras activation occur, concurrently, at the same sites where F-actin projection emerges, suggesting that PI3k and Ras form a positive feedback circuit.