Chris van Oevelen

TL;DR: This work studies genome topology dynamics during reprogramming of different somatic cell types with highly distinct genome conformations to find large-scale topologically associated domain (TAD) repositioning and alterations of tissue-restricted genomic neighborhoods and chromatin loops, effectively erasing the somatic-cell-specific genome structures while establishing an embryonic stem-cell like 3D genome.

TL;DR: The authors showed that a pulse of CCAAT/enhancer binding protein-α (C/EBPα) followed by overexpression of the Yamanaka 'OSKM' reprogramming factors leads to fast and very efficient B-cell precursors to induced pluripotent stem (iPS) cells.

TL;DR: It is demonstrated that pRb effects permanent cell cycle exit in part by maintaining trimethylation of histone H3 lysine 27 (H3K27) on cell cycle genes, which distinguish two distinct chromatin-based regulatory mechanisms that lead to terminal differentiation.

TL;DR: Investigation of genome-wide binding of mouse Sin3 and RBP2 as well as histone modifications and nucleosome positioning as a function of myogenic differentiation suggests a model in which spreading of Sin3 binding is ultimately linked to permanent gene silencing on a subset of E2F4 target genes.

TL;DR: Focusing on B-cell and macrophage development, a qualitative dynamical model recapitulating cytokine-induced differentiation of common progenitors, the effect of various reported gene knockdowns, and the reprogramming of pre-B cells into macrophages induced by the ectopic expression of specific transcription factors is defined.