C
Christian Flueck
Researcher at University of London
Publications - 26
Citations - 1284
Christian Flueck is an academic researcher from University of London. The author has contributed to research in topics: Plasmodium falciparum & Protein kinase A. The author has an hindex of 16, co-authored 25 publications receiving 1079 citations. Previous affiliations of Christian Flueck include Swiss Tropical and Public Health Institute & University of Basel.
Papers
More filters
Journal ArticleDOI
Plasmodium falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors
Christian Flueck,Richárd Bártfai,Jennifer Volz,Igor Niederwieser,Adriana M. Salcedo-Amaya,Blaise T. F. Alako,Florian Ehlgen,Stuart A. Ralph,Alan F. Cowman,Zbynek Bozdech,Hendrik G. Stunnenberg,Till S. Voss +11 more
TL;DR: It is shown that P. falciparum heterochromatin protein 1 (PfHP1) binds specifically to H3K9me3 but not to other repressive histone methyl marks, which identifies PfHP1 as a major effector of virulence gene silencing and phenotypic variation.
Journal ArticleDOI
A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology
Christian Flueck,Richárd Bártfai,Igor Niederwieser,Kathrin Witmer,Blaise T. F. Alako,Suzette Moes,Zbynek Bozdech,Paul Jenoe,Hendrik G. Stunnenberg,Till S. Voss +9 more
TL;DR: Contrary to the previously proposed role for this factor in gene activation, the results provide strong evidence for the first time for the involvement of an ApiAP2 factor in heterochromatin formation and genome integrity.
Journal ArticleDOI
Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion
Mahmood M. Alam,Lev Solyakov,Andrew R. Bottrill,Christian Flueck,Faiza Amber Siddiqui,Shailja Singh,Sharad Mistry,Maria Viskaduraki,Kate D. Lee,Christine S. Hopp,Chetan E. Chitnis,Christian Doerig,Robert W. Moon,Judith L. Green,Anthony A. Holder,David A. Baker,Andrew B. Tobin +16 more
TL;DR: The phosphorylation sites on 69 proteins involved in cell signalling, proteolysis, gene regulation, protein export and ion and protein transport are identified, indicating that cGMP/PfPKG acts as a signalling hub that plays a central role in a number of core parasite processes.
Journal ArticleDOI
Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum
Sophie Clara Oehring,Sophie Clara Oehring,Ben J. Woodcroft,Suzette Moes,Johanna Wetzel,Johanna Wetzel,Olivier Dietz,Olivier Dietz,Andreas Pulfer,Andreas Pulfer,Chaitali Dekiwadia,Pascal Maeser,Pascal Maeser,Christian Flueck,Christian Flueck,Kathrin Witmer,Kathrin Witmer,Nicolas M. B. Brancucci,Nicolas M. B. Brancucci,Igor Niederwieser,Igor Niederwieser,Paul Jenoe,Stuart A. Ralph,Till S. Voss,Till S. Voss +24 more
TL;DR: This study provides comprehensive new insight into the biology of the Plasmodium nucleus and will serve as an important platform for dissecting general and parasite-specific nuclear processes in malaria parasites and provide an important resource for studying evolutionary aspects of nuclear biology.
Journal ArticleDOI
Plasmodium falciparum centromeres display a unique epigenetic makeup and cluster prior to and during schizogony.
Wieteke A. M. Hoeijmakers,Christian Flueck,Christian Flueck,Kees-Jan Francoijs,Arne H. Smits,Johanna Wetzel,Johanna Wetzel,Jennifer Volz,Alan F. Cowman,Till S. Voss,Till S. Voss,Hendrik G. Stunnenberg,Richárd Bártfai +12 more
TL;DR: A dynamic association of Plasmodium centromeres is revealed, which bear a unique epigenetic signature and conform to a strict structure, which suggests that DNA‐associated and epigenetic elements play an important role in centromere establishment in this important human pathogen.