C
Christine M. Freeman
Researcher at University of Michigan
Publications - 78
Citations - 4970
Christine M. Freeman is an academic researcher from University of Michigan. The author has contributed to research in topics: COPD & Lung. The author has an hindex of 28, co-authored 67 publications receiving 3860 citations. Previous affiliations of Christine M. Freeman include Veterans Health Administration & United States Department of Veterans Affairs.
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Journal ArticleDOI
Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD
John R. Erb-Downward,Deborah L. Thompson,MeiLan K. Han,Christine M. Freeman,Christine M. Freeman,Lisa McCloskey,Lisa McCloskey,Lindsay A. Schmidt,Vincent B. Young,Galen B. Toews,Galen B. Toews,Jeffrey L. Curtis,Jeffrey L. Curtis,Baskaran Sundaram,Fernando J. Martinez,Gary B. Huffnagle +15 more
TL;DR: The data suggests the existence of a core pulmonary bacterial microbiome that includes Pseudomonas, Streptococcus, Prevotella, Fusobacterium, Haemophilus, Veillonella, and Porphyromonas within the same lung of subjects with advanced COPD.
Journal ArticleDOI
Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals
Christine M. Bassis,John R. Erb-Downward,Robert P. Dickson,Christine M. Freeman,Thomas M. Schmidt,Vincent B. Young,James M. Beck,James M. Beck,Jeffrey L. Curtis,Gary B. Huffnagle +9 more
TL;DR: Molecular immigration from the oral cavity appears to be the significant source of the lung microbiome during health, but unlike the stomach, the lungs exhibit evidence of selective elimination of Prevotella bacteria derived from the upper airways.
Journal ArticleDOI
Spatial Variation in the Healthy Human Lung Microbiome and the Adapted Island Model of Lung Biogeography
Robert P. Dickson,John R. Erb-Downward,Christine M. Freeman,Lisa McCloskey,James M. Beck,James M. Beck,Gary B. Huffnagle,Jeffrey L. Curtis +7 more
TL;DR: The lung microbiome in health is more influenced by microbial immigration and elimination (the adapted island model) than by the effects of local growth conditions on bacterial reproduction rates, which are more determinant in advanced lung diseases.
Journal ArticleDOI
Bacterial Topography of the Healthy Human Lower Respiratory Tract.
Robert P. Dickson,John R. Erb-Downward,Christine M. Freeman,Lisa McCloskey,Nicole R. Falkowski,Gary B. Huffnagle,Jeffrey L. Curtis +6 more
TL;DR: The bacterial topography of the healthy human respiratory tract is defined and ecological evidence that bacteria enter the lungs in health primarily by microaspiration, with potential contribution in some subjects by direct dispersal along contiguous mucosa, is provided.
Journal ArticleDOI
Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort
MeiLan K. Han,Pedro Miguel Quibrera,Elizabeth E. Carretta,R. Graham Barr,Eugene R. Bleecker,Russell P. Bowler,Christopher B. Cooper,A.P. Comellas,David Couper,Jeffrey L. Curtis,Gerard J. Criner,Mark T. Dransfield,Nadia N. Hansel,Eric A. Hoffman,Richard E. Kanner,Jerry A. Krishnan,Carlos H. Martinez,Cheryl B Pirozzi,Wanda K. O'Neal,Stephen I. Rennard,Stephen I. Rennard,Donald P. Tashkin,Jadwiga A. Wedzicha,Prescott G. Woodruff,Robert Paine,Robert Paine,Fernando J. Martinez,Neil E. Alexis,Wayne Anderson,Richard C. Boucher,Stephanie A Christenson,Alejandro P. Comellas,Gerard J. Criner,Ronald G. Crystal,Claire M. Doerschuk,Christine M. Freeman,Annette T. Hastie,Robert J. Kaner,Eric C. Kleerup,Lisa M. LaVange,Stephen C. Lazarus,Deborah A. Meyers,John D. Newell,Elizabeth C. Oelsner,Nirupama Putcha,Stephen I. Rennard,Stephen I. Rennard,Mary Beth Scholand,J. Michael Wells,Robert A. Wise,P.G. Woodruff +50 more
TL;DR: This longitudinal, prospective analysis of exacerbations in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) cohort identified several novel biomarkers associated with consistent exacerbations, including CT-defined small airway abnormality on CT, lower interleukin-15 concentrations, and higher interleucin-8 concentrations.