J
J. Michael Wells
Researcher at University of Alabama at Birmingham
Publications - 102
Citations - 4121
J. Michael Wells is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: COPD & Exacerbation. The author has an hindex of 27, co-authored 95 publications receiving 2930 citations. Previous affiliations of J. Michael Wells include University of North Carolina at Chapel Hill & University of Alabama.
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Journal ArticleDOI
Pulmonary arterial enlargement and acute exacerbations of COPD.
J. Michael Wells,George R. Washko,MeiLan K. Han,Naseer Abbas,Hrudaya Nath,A. James Mamary,Elizabeth A. Regan,William C. Bailey,Fernando J. Martinez,Elizabeth Westfall,Terri H. Beaty,Douglas Curran-Everett,Jeffrey L. Curtis,Jeffrey L. Curtis,John E. Hokanson,David A. Lynch,Barry J. Make,James D. Crapo,Edwin K. Silverman,Russell P. Bowler,Mark T. Dransfield,Mark T. Dransfield +21 more
TL;DR: In this article, a multivariate logistic-regression analysis showed a significant association between a PA:A ratio of more than 1 and a history of severe exacerbations at the time of enrollment in the trial (odds ratio, 4.78; 95% confidence interval [CI], 3.43 to 6.65; P 1).
Journal ArticleDOI
Association between functional small airway disease and FEV1 decline in chronic obstructive pulmonary disease
Surya P. Bhatt,Xavier Soler,Xin Wang,Susan Murray,Antonio Anzueto,Terri H. Beaty,Aladin M. Boriek,Richard Casaburi,Gerard J. Criner,Alejandro A. Diaz,Mark T. Dransfield,Douglas Curran-Everett,Craig J. Galbán,Eric A. Hoffman,Eric A. Hoffman,James C. Hogg,Ella A. Kazerooni,Victor Kim,Gregory L. Kinney,Amir Lagstein,David A. Lynch,Barry J. Make,Fernando J. Martinez,Joe W. Ramsdell,Rishindra M. Reddy,Brian D. Ross,Harry B. Rossiter,Robert M. Steiner,Matthew Strand,Edwin J R van Beek,Emily S. Wan,George R. Washko,J. Michael Wells,Chris H. Wendt,Robert A. Wise,Edwin K. Silverman,James D. Crapo,Russell P. Bowler,MeiLan K. Han +38 more
TL;DR: CT-assessed functional small airway disease and emphysema are associated with FEV1 decline, but the association with functional smallAirway disease has greatest importance in mild-to-moderate stage chronic obstructive pulmonary disease where the rate of FEV 1 decline is the greatest.
Journal ArticleDOI
Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.
Kristopher R. Genschmer,Derek W Russell,Charitharth Vivek Lal,Tomasz Szul,Preston E. Bratcher,Brett D. Noerager,Mojtaba Abdul Roda,Xin Xu,Gabriel Rezonzew,Liliana Viera,Brian S. Dobosh,Camilla Margaroli,Tarek Abdalla,Robert W. King,Carmel M. McNicholas,J. Michael Wells,Mark T. Dransfield,Rabindra Tirouvanziam,Amit Gaggar,J. Edwin Blalock +19 more
TL;DR: Findings reveal an unappreciated role for exosomes in the pathogenesis of disorders of ECM homeostasis such as COPD and BPD, providing a critical mechanism for proteolytic damage.
Journal ArticleDOI
Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort
MeiLan K. Han,Pedro Miguel Quibrera,Elizabeth E. Carretta,R. Graham Barr,Eugene R. Bleecker,Russell P. Bowler,Christopher B. Cooper,A.P. Comellas,David Couper,Jeffrey L. Curtis,Gerard J. Criner,Mark T. Dransfield,Nadia N. Hansel,Eric A. Hoffman,Richard E. Kanner,Jerry A. Krishnan,Carlos H. Martinez,Cheryl B Pirozzi,Wanda K. O'Neal,Stephen I. Rennard,Stephen I. Rennard,Donald P. Tashkin,Jadwiga A. Wedzicha,Prescott G. Woodruff,Robert Paine,Robert Paine,Fernando J. Martinez,Neil E. Alexis,Wayne Anderson,Richard C. Boucher,Stephanie A Christenson,Alejandro P. Comellas,Gerard J. Criner,Ronald G. Crystal,Claire M. Doerschuk,Christine M. Freeman,Annette T. Hastie,Robert J. Kaner,Eric C. Kleerup,Lisa M. LaVange,Stephen C. Lazarus,Deborah A. Meyers,John D. Newell,Elizabeth C. Oelsner,Nirupama Putcha,Stephen I. Rennard,Stephen I. Rennard,Mary Beth Scholand,J. Michael Wells,Robert A. Wise,P.G. Woodruff +50 more
TL;DR: This longitudinal, prospective analysis of exacerbations in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) cohort identified several novel biomarkers associated with consistent exacerbations, including CT-defined small airway abnormality on CT, lower interleukin-15 concentrations, and higher interleucin-8 concentrations.
Journal ArticleDOI
Acute Exacerbations and Lung Function Loss in Smokers with and without Chronic Obstructive Pulmonary Disease
Mark T. Dransfield,Mark T. Dransfield,Ken M. Kunisaki,Ken M. Kunisaki,Matthew Strand,Antonio Anzueto,Antonio Anzueto,Surya P. Bhatt,Russell P. Bowler,Gerard J. Criner,Jeffrey L. Curtis,Nicola A. Hanania,Hrudaya Nath,Nirupama Putcha,Sarah E. Roark,Emily S. Wan,George R. Washko,J. Michael Wells,Christine H. Wendt,Christine H. Wendt,Barry J. Make +20 more
TL;DR: Exacerbations are associated with accelerated lung function loss in subjects with established COPD, particularly those with mild disease, and trials are needed to test existing and novel therapies in Subjects with early/mild COPD to potentially reduce the risk of progressing to more advanced lung disease.