C
Christine Patch
Researcher at Queen Mary University of London
Publications - 115
Citations - 2358
Christine Patch is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Genetic testing & Medicine. The author has an hindex of 21, co-authored 95 publications receiving 1638 citations. Previous affiliations of Christine Patch include University College London & Sheffield Hallam University.
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Journal ArticleDOI
The 100 000 Genomes Project: bringing whole genome sequencing to the NHS
Clare Turnbull,Richard H Scott,Ellen Thomas,Louise Jones,N. Murugaesu,Freya Boardman Pretty,Dina Halai,Emma L. Baple,C. E. H. Craig,Angela Hamblin,Shirley Henderson,Christine Patch,Christine Patch,Amanda O’Neill,Andrew D. Devereau,Katherine R. Smith,Antonio Rueda Martin,Alona Sosinsky,Ellen M. McDonagh,Razvan Sultana,Michael J. Mueller,Damian Smedley,Adam Toms,Lisa Dinh,Tom Fowler,Mark Bale,Tim Hubbard,Augusto Rendon,Sue Hill,Mark J. Caulfield +29 more
TL;DR: Genomics England’s ambitious plans to embed genomic medicine into routine patient care are well underway and Clare Turnbull and colleagues discuss its progress.
Journal ArticleDOI
Whole-genome sequencing reveals host factors underlying critical COVID-19
Athanasios Kousathanas,Erola Pairo-Castineira,Konrad Rawlik,Alexander Stuckey,Christopher A. Odhams,S. Walker,Clark D Russell,Tomas Malinauskas,Yang Wu,Jonathan E Millar,Xia Shen,Katherine S. Elliott,Fiona Griffiths,Wilna Oosthuyzen,K.W. Morrice,Seán Keating,Bo Wang,Daniel R. Rhodes,Lucija Klaric,Marie Zechner,Nicholas J. Parkinson,Afshan Siddiq,Peter GoddardP. Goddard,Sally Donovan,David M. Maslove,Alistair Nichol,Malcolm G Semple,Tala Zainy,Fiona Maleady-Crowe,L. Todd,Shahla Karbalaei Salehi,Julian C. Knight,Greg Elgar,G. Chan,Prabhu Arumugam,Christine Patch,Augusto Rendon,David Bentley,Clarence D. Kingsley,Jack A. Kosmicki,Julie Horowitz,Aris Baras,Gonçalo R. Abecasis,Manuel A. R. Ferreira,Anne E. Justice,Tooraj Mirshahi,Matthew T. Oetjens,Daniel J. Rader,Marylyn D. Ritchie,Anurag Verma,Tom Fowler,Manu Shankar-Hari,Charlotte Summers,Charles J. Hinds,Peter Horby,Lowell Ling,D. McAuley,Hugh Montgomery,Peter J. M. Openshaw,Paul Elliott,Timothy S. Walsh,Albert Tenesa,Angie Fawkes,Lee Murphy,Kathryn M Rowan,Chris P. Ponting,Veronique Vitart,James F. Wilson,Andrew D. Bretherick,Richard T. Scott,Sara Clohisey Hendry,Loukas Moutsianas,Andy Law,Mark J. Caulfield,J Kenneth Baillie +74 more
TL;DR: The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms as mentioned in this paper .
Journal ArticleDOI
Penetrance for copy number variants associated with schizophrenia
Evangelos Vassos,David A. Collier,Simon Holden,Christine Patch,Dan Rujescu,David St Clair,Cathryn M. Lewis +6 more
TL;DR: Although CNVs are still far from being clinically useful or relevant to genetic counselling for specific disorders, their detection may hold an important clinical value in predicting negative developmental outcomes.
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How can the evaluation of genetic tests be enhanced? Lessons learned from the ACCE framework and evaluating genetic tests in the United Kingdom.
TL;DR: A number of conceptual, methodological, and practical issues concerning the evaluation of genetic tests are discussed, based on lessons learned from applying the ACCE framework and from the UK experience, and a number of recommendations are made to further strengthen the evaluationof genetic tests.
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Use of Antihypertensive Medications and Mortality of Patients With Autosomal Dominant Polycystic Kidney Disease: A Population-Based Study
TL;DR: There was evidence of a trend toward decreasing mortality as the number of antihypertensive drug classes prescribed in a year increased, and increasing coverage and intensity of anti Hypertensive therapy is associated with decreasing mortality in people with ADPKD.