M
Matthew T. Oetjens
Researcher at University of Michigan
Publications - 37
Citations - 1700
Matthew T. Oetjens is an academic researcher from University of Michigan. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 14, co-authored 28 publications receiving 1156 citations. Previous affiliations of Matthew T. Oetjens include Vanderbilt University & University of Rochester.
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Journal ArticleDOI
Genetic variants associated with warfarin dose in African- American individuals: a genome-wide association study
Minoli A. Perera,Larisa H. Cavallari,Nita A. Limdi,Eric R. Gamazon,Anuar Konkashbaev,Roxana Daneshjou,Anna Pluzhnikov,Dana C. Crawford,Jelai Wang,Nianjun Liu,Nicholas P. Tatonetti,Stephane Bourgeois,Harumi Takahashi,Yukiko Bradford,Benjamin Burkley,Robert J. Desnick,Jonathan L. Halperin,Sherief Khalifa,Taimour Y. Langaee,Steven A. Lubitz,Edith A. Nutescu,Matthew T. Oetjens,Mohamed H. Shahin,Shitalben R. Patel,Hersh Sagreiya,Matthew Tector,Karen E. Weck,Mark J. Rieder,Stuart A. Scott,Alan H.B. Wu,James K. Burmester,Mia Wadelius,Panos Deloukas,Michael J. Wagner,Taisei Mushiroda,Michiaki Kubo,Dan M. Roden,Nancy J. Cox,Russ B. Altman,Teri E. Klein,Yusuke Nakamura,Julie A. Johnson +41 more
TL;DR: A novel CYP2C single nucleotide polymorphism exerts a clinically relevant effect on warfarin dose in African Americans, independent of CYP 2C9*2 and CYP9*3, and incorporation of this variant into pharmacogenetic dosing algorithms could improve warFarin dose prediction in this population.
Journal ArticleDOI
Unravelling the human genome-phenome relationship using phenome-wide association studies
TL;DR: These studies reveal a number of challenges that will need to be overcome to unlock the full potential of PheWAS for the characterization of the complex human genome–phenome relationship.
Journal ArticleDOI
Ancient European dog genomes reveal continuity since the Early Neolithic.
Laura R. Botigué,Shiya Song,Amelie Scheu,Shyamalika Gopalan,Amanda L. Pendleton,Matthew T. Oetjens,Angela M. Taravella,Timo Seregély,Andrea Zeeb-Lanz,Rose-Marie Arbogast,Dean Bobo,Kevin G. Daly,Martina Unterländer,Joachim Burger,Jeffrey M. Kidd,Krishna R. Veeramah +15 more
TL;DR: The genomes of an Early and End Neolithic dog from Germany demonstrate continuity with each other and predominantly share ancestry with modern European dogs, contradicting a previously suggested Late Neolithic population replacement.
Journal ArticleDOI
Whole-genome sequencing reveals host factors underlying critical COVID-19
Athanasios Kousathanas,Erola Pairo-Castineira,Konrad Rawlik,Alexander Stuckey,Christopher A. Odhams,S. Walker,Clark D Russell,Tomas Malinauskas,Yang Wu,Jonathan E Millar,Xia Shen,Katherine S. Elliott,Fiona Griffiths,Wilna Oosthuyzen,K.W. Morrice,Seán Keating,Bo Wang,Daniel R. Rhodes,Lucija Klaric,Marie Zechner,Nicholas J. Parkinson,Afshan Siddiq,Peter GoddardP. Goddard,Sally Donovan,David M. Maslove,Alistair Nichol,Malcolm G Semple,Tala Zainy,Fiona Maleady-Crowe,L. Todd,Shahla Karbalaei Salehi,Julian C. Knight,Greg Elgar,G. Chan,Prabhu Arumugam,Christine Patch,Augusto Rendon,David Bentley,Clarence D. Kingsley,Jack A. Kosmicki,Julie Horowitz,Aris Baras,Gonçalo R. Abecasis,Manuel A. R. Ferreira,Anne E. Justice,Tooraj Mirshahi,Matthew T. Oetjens,Daniel J. Rader,Marylyn D. Ritchie,Anurag Verma,Tom Fowler,Manu Shankar-Hari,Charlotte Summers,Charles J. Hinds,Peter Horby,Lowell Ling,D. McAuley,Hugh Montgomery,Peter J. M. Openshaw,Paul Elliott,Timothy S. Walsh,Albert Tenesa,Angie Fawkes,Lee Murphy,Kathryn M Rowan,Chris P. Ponting,Veronique Vitart,James F. Wilson,Andrew D. Bretherick,Richard T. Scott,Sara Clohisey Hendry,Loukas Moutsianas,Andy Law,Mark J. Caulfield,J Kenneth Baillie +74 more
TL;DR: The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms as mentioned in this paper .
Journal ArticleDOI
An Evolutionary Genomic Approach to Identify Genes Involved in Human Birth Timing
Jevon Plunkett,Scott W. Doniger,Guilherme Orabona,Thomas Morgan,Ritva Haataja,Mikko Hallman,Hilkka Puttonen,Ramkumar Menon,Edward Kuczynski,Errol R. Norwitz,Victoria Snegovskikh,Aarno Palotie,Aarno Palotie,Aarno Palotie,Leena Peltonen,Leena Peltonen,Leena Peltonen,Vineta Fellman,Vineta Fellman,Emily DeFranco,Bimal P. Chaudhari,Tracy L. McGregor,Jude J. McElroy,Matthew T. Oetjens,Kari Teramo,Ingrid B. Borecki,Justin C. Fay,Louis J. Muglia +27 more
TL;DR: In this article, the authors identified a novel gene that may be associated with preterm birth, FSHR, and found that 8 of the 10 most significant SNPs were in this gene.