Christopher A. Powell

TL;DR: A second primase in human cells, PrimPol, is described, which has the ability to start DNA chains with deoxynucleotides unlike regular primases, which use exclusively ribonucleotide, which is a DNA polymerase tailored to bypass the most common oxidative lesions in DNA.

TL;DR: Findings constitute proof of principle that mtDNA heteroplasmy correction using programmable nucleases could provide a therapeutic route for heteroplasmic mitochondrial diseases of diverse genetic origin.

TL;DR: It is shown that NSun3 is required for deposition of m5C at the anticodon loop in the mitochondrially encoded transfer RNA methionine (mt-tRNAMet), and f5C in human mitochondrial RNA is generated by oxidative processing of m 5C.

TL;DR: The latest breakthroughs in understanding of the post-transcriptional processes of mitochondrial gene expression are reviewed, focusing on advances in analyzing the mitochondrial epitranscriptome, the role of mitochondrial RNA granules (MRGs), the benefits of recently obtained structures of the mitochondrial ribosome, and the coordination of mitochondrial and cytosolic translation to orchestrate the biogenesis of OxPhos complexes.

TL;DR: The study of a mitochondrial translation disorder points toward the importance of posttranscriptional modification of mitochondrial tRNAs for proper mitochondrial function.