C
Christopher Vollmers
Researcher at University of California, Santa Cruz
Publications - 71
Citations - 6263
Christopher Vollmers is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Transcriptome & Gene. The author has an hindex of 25, co-authored 61 publications receiving 4867 citations. Previous affiliations of Christopher Vollmers include Stanford University & Heidelberg University.
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Journal ArticleDOI
Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging.
Charles F. A. de Bourcy,Cesar J. Lopez Angel,Christopher Vollmers,Cornelia L. Dekker,Mark M. Davis,Mark M. Davis,Stephen R. Quake +6 more
TL;DR: A direct molecular characterization of the effects of aging on the adaptive immune system by high-throughput sequencing of antibody transcripts in the peripheral blood of humans is reported, indicating that BCR repertoires become increasingly specialized over a span of decades, but less plastic.
Journal ArticleDOI
Signatures of selection in the human antibody repertoire: Selective sweeps, competing subclones, and neutral drift
TL;DR: In this article, the authors measured the dynamics and genetic diversity of B cell responses in five adults longitudinally before and after influenza vaccination using high-throughput antibody repertoire sequencing and found vaccine-responsive B cell lineages that carry signatures of selective sweeps driven by positive selection.
Journal ArticleDOI
Realizing the potential of full-length transcriptome sequencing.
TL;DR: In this review, the limitations of short-read sequencing technology and how long- read sequencing technology overcomes these limitations are outlined and some suggestions on how to overcome these challenges going forward are provided.
Journal ArticleDOI
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment.
Cleber A. Trujillo,Edward S. Rice,Nathan K. Schaefer,Isaac A. Chaim,Emily C. Wheeler,Assael A. Madrigal,Justin Buchanan,Sebastian Preissl,Allen Wang,Priscilla D. Negraes,Ryan A. Szeto,Roberto H. Herai,Alik Huseynov,Mariana Sacrini Ayres Ferraz,Fernando S. Borges,Alexandre Hiroaki Kihara,Ashley Byrne,Maximillian G. Marin,Christopher Vollmers,Angela N. Brooks,Jonathan D. Lautz,Jonathan D. Lautz,Katerina Semendeferi,Beth Shapiro,Gene W. Yeo,Stephen E. P. Smith,Stephen E. P. Smith,Richard E. Green,Alysson R. Muotri +28 more
TL;DR: In this paper, the evolutionarily conserved splicing regulator neuro-oncological ventral antigen 1 (NOVA1) plays a key role in neural development and function.
Posted ContentDOI
Nanopore Long-Read RNAseq Reveals Widespread Transcriptional Variation Among the Surface Receptors of Individual B cells
Ashley Byrne,Anna E. Beaudin,Hugh E. Olsen,Miten Jain,Charles Cole,Theron Palmer,Rebecca M. DuBois,E. Camilla Forsberg,Mark Akeson,Christopher Vollmers +9 more
TL;DR: Results show that not only can RNAseq using the long-read single-molecule Oxford Nanopore MinION sequencing technology be able to identify and quantify complex isoforms without sacrificing accurate gene expression quantification, at the single cell level.