Maximillian G. Marin

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The most comprehensive catalogue of cancer-associated gene alterations to date, obtained by characterizing tumour transcriptomes from 1,188 donors of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Gome Atlas (TCGA) was presented in this article.

TL;DR: In this paper, the evolutionarily conserved splicing regulator neuro-oncological ventral antigen 1 (NOVA1) plays a key role in neural development and function.

TL;DR: This study represents an extensive catalog of RNA alterations and reveals new insights into the heterogeneous molecular mechanisms of cancer gene alterations, which differ between cancer types and have associations with DNA mutational signatures.

TL;DR: This work presents the most comprehensive catalogue of cancer-associated gene alterations through extensive characterization of tumor transcriptomes from 1,188 donors of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project with matched whole-genome sequence data.