IL-4 Induces Characteristic Th2 Responses Even in the Combined Absence of IL-5, IL-9, and IL-13
Padraic G. Fallon,Helen E. Jolin,Philippa Smith,Claire Emson,Michael J. Townsend,Rosie E. Fallon,Philip Smith,Andrew N. J. McKenzie +7 more
TLDR
It is found that these Th2 cytokines are not essential for fetal survival even during allogeneic pregnancy, and a threshold is reached at which IL-4 alone can activate all Th2 effector functions.About:
This article is published in Immunity.The article was published on 2002-07-01 and is currently open access. It has received 329 citations till now. The article focuses on the topics: Cytokine & Interleukin 4.read more
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Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
Journal ArticleDOI
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill,See Heng Wong,Agustin Bellosi,Robin J. Flynn,Maria Daly,Theresa K. A. Langford,Christine Bucks,Colleen M. Kane,Padraic G. Fallon,Richard Pannell,Helen E. Jolin,Andrew N.J. McKenzie +11 more
TL;DR: The identification and functional characterization of a new innate type-2 immune effector leukocyte that is named the nuocyte is presented, which represents a critically important innate effector cell in type- 2 immunity.
Journal ArticleDOI
Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
April E. Price,Hong-Erh Liang,Brandon M. Sullivan,R. Lee Reinhardt,Chris J. Eisley,David J. Erle,Richard M. Locksley +6 more
TL;DR: In this paper, lineage-negative IL-25 and IL-33 responsive cells are found to be widely distributed in tissues of the mouse and are particularly prevalent in mesenteric lymph nodes, spleen, and liver.
Journal ArticleDOI
Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy
TL;DR: In this article, the authors reviewed the immunological environment in normal pregnancy and complicated pregnancy from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.
Journal ArticleDOI
Immunology of placentation in eutherian mammals.
Ashley Moffett,Charlie Loke +1 more
TL;DR: The traditional way to study the immunology of pregnancy follows the classical transplantation model, which views the fetus as an allograft, but a more recent approach focuses on the unique, local uterine immune response to the implanting placenta.
References
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Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?
TL;DR: In this article, the authors hypothesize that TH2 cytokines inhibit TH1 responses, improving fetal survival but impairing responses against some pathogens, since pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell mediated immunity.
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Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
Gabriele Grünig,Martha L. Warnock,Adil E. Wakil,Rajeev Venkayya,Frank Brombacher,Donna M. Rennick,Dean Sheppard,Markus Mohrs,Debra D. Donaldson,Richard M. Locksley,David B. Corry +10 more
TL;DR: This article showed that IL-4 receptor α chain-dependent pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL4 receptor and showed that selective neutralization of IL-13, a cytokine related to interleukin-4 that also binds to the α chain of the IL 4 receptor, ameliorated asthma phenotype.
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Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
Margaret J Leckie,Anneke ten Brinke,Jamey Khan,Zuzana Diamant,Brian J. O'Connor,Christine M Walls,A. Mathur,Hugh C Cowley,K. Fan Chung,Ratko Djukanovic,Trevor T. Hansel,Stephen T. Holgate,Peter J. Sterk,Peter J. Barnes +13 more
TL;DR: A single dose of monoclonal antibody to IL-5 decreased blood eosinophils for up to 16 weeks and sputum eosInophils at 4 weeks, which has considerable therapeutic potential for asthma and allergy, however, the findings question the role of eos inophils in mediating the late asthmatic response and causing airway hyper-responsiveness.