Effect of generalised access to early diagnosis and treatment and targeted mass drug administration on Plasmodium falciparum malaria in Eastern Myanmar: an observational study of a regional elimination programme
Jordi Landier,Jordi Landier,Daniel M. Parker,Daniel M. Parker,Aung Myint Thu,Khin Maung Lwin,Gilles Delmas,Gilles Delmas,François Nosten,François Nosten,Chiara Andolina,Ricardo Aguas,Saw Moe Ang,Ei Phyo Aung,Naw Baw Baw,Saw Aye Be,Saw B'Let,Hay Bluh,Craig A. Bonnington,Victor Chaumeau,Miasa Chirakiratinant,Win Cho Cho,Peter R. Christensen,Vincent Corbel,Nicholas P. J. Day,Saw Hsa Dah,Mehul Dhorda,Arjen M. Dondorp,Jean Gaudart,Gornpan Gornsawun,Warat Haohankhunnatham,Saw Kyaw Hla,Saw Nay Hsel,Saw Nay Htoo,Mallika Imwong,Saw John,Ladda Kajeechiwa,Lily Kereecharoen,Praphan Kittiphanakun,Keerati Kittitawee,Kamonchanok Konghahong,Saw Diamond Khin,Saw Win Kyaw,Clare L. Ling,Khine Shwe War Lwin,Naw K' Yin Ma,Alexandra Marie,Cynthia Maung,Ed Marta,Myo Chit Minh,Olivo Miotto,Paw Khu Moo,Ku Ler Moo,Merry Moo,Naw Na Na,Mar Nay,Suphak Nosten,Slight Naw Nyo,Eh Kalu Shwe Oh,Phu Thit Oo,Tun Pyit Oo,Eh Shee Paw,Choochai Phumiya,Aung Pyae Phyo,Kasiha Pilaseng,Stephane Proux,Santisuk Rakthinthong,Wannee Ritwongsakul,Kloloi Salathibuphha,Armon Santirad,Sunisa Sawasdichai,Lorenz von Seidlein,Paw Wah Shee,Paw Bway Shee,Decha Tangseefa,May Myo Thwin,Saw Win Tun,Chode Wanachaloemlep,Lisa J. White,Nicholas J. White,Jacher Wiladphaingern,Saw Nyunt Win,Nan Lin Yee,Daraporn Yuwapan +83 more
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TLDR
Providing early diagnosis and effective treatment substantially decreased village-level incidence of artemisinin-resistant P falciparum malaria in hard-to-reach, politically sensitive regions of eastern Myanmar.About:
This article is published in The Lancet.The article was published on 2018-05-12 and is currently open access. It has received 119 citations till now. The article focuses on the topics: Malaria & Plasmodium falciparum.read more
Citations
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Journal ArticleDOI
The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density
Hannah C Slater,Amanda Ross,Amanda Ross,Ingrid Felger,Ingrid Felger,Natalie E. Hofmann,Natalie E. Hofmann,Leanne J. Robinson,Jackie Cook,Bronner P. Gonçalves,Anders Björkman,André Lin Ouédraogo,Ulrika Morris,Mwinyi I. Msellem,Cristian Koepfli,Cristian Koepfli,Ivo Mueller,Ivo Mueller,Ivo Mueller,Fitsum G. Tadesse,Fitsum G. Tadesse,Endalamaw Gadisa,Smita Das,Gonzalo J. Domingo,Melissa C. Kapulu,Melissa C. Kapulu,Janet Midega,Janet Midega,Seth Owusu-Agyei,Cécile Nabet,Renaud Piarroux,Ogobara K. Doumbo,Safiatou Doumbo,Kwadwo A. Koram,Naomi W. Lucchi,Venkatachalam Udhayakumar,Jacklin F. Mosha,Alfred B. Tiono,Daniel Chandramohan,Roly Gosling,Felista Mwingira,Robert W. Sauerwein,Richard Paul,Eleanor M. Riley,Eleanor M. Riley,Nicholas J. White,Nicholas J. White,François Nosten,François Nosten,Mallika Imwong,Teun Bousema,Teun Bousema,Chris Drakeley,Lucy C Okell +53 more
TL;DR: Results indicate that subpatent infections contribute to the infectious reservoir, may be long lasting, and require more sensitive diagnostics to detect them in lower transmission settings.
Journal ArticleDOI
The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial
Lorenz von Seidlein,Lorenz von Seidlein,Thomas J. Peto,Thomas J. Peto,Jordi Landier,Jordi Landier,Thuy-Nhien Nguyen,Rupam Tripura,Rupam Tripura,Rupam Tripura,Koukeo Phommasone,Koukeo Phommasone,Tiengkham Pongvongsa,Khin Maung Lwin,Lilly Keereecharoen,Ladda Kajeechiwa,May Myo Thwin,Daniel M. Parker,Daniel M. Parker,Jacher Wiladphaingern,Suphak Nosten,Stephane Proux,Vincent Corbel,Nguyen Tuong-Vy,Truong Le Phuc-Nhi,Do Hung Son,Pham Nguyen Huong-Thu,Nguyen Thi Kim Tuyen,Nguyen Thanh Tien,Le Thanh Dong,Dao Van Hue,Huynh Hong Quang,Chea Nguon,Chan Davoeung,Huy Rekol,Bipin Adhikari,Bipin Adhikari,Gisela Henriques,Gisela Henriques,Panom Phongmany,Preyanan Suangkanarat,Atthanee Jeeyapant,Benchawan Vihokhern,Rob W. van der Pluijm,Rob W. van der Pluijm,Yoel Lubell,Yoel Lubell,Lisa J. White,Lisa J. White,Ricardo Aguas,Ricardo Aguas,Cholrawee Promnarate,Pasathorn Sirithiranont,Benoit Malleret,Benoit Malleret,Laurent Rénia,Carl Onsjö,Carl Onsjö,Xin Hui S Chan,Xin Hui S Chan,Jeremy Chalk,Olivo Miotto,Olivo Miotto,Krittaya Patumrat,Kesinee Chotivanich,Borimas Hanboonkunupakarn,Podjanee Jittmala,Nils Kaehler,Phaik Yeong Cheah,Phaik Yeong Cheah,Christopher Pell,Mehul Dhorda,Mallika Imwong,Georges Snounou,Mavuto Mukaka,Mavuto Mukaka,Pimnara Peerawaranun,Sue J. Lee,Sue J. Lee,Julie A. Simpson,Sasithon Pukrittayakamee,Sasithon Pukrittayakamee,Pratap Singhasivanon,Martin P. Grobusch,Frank Cobelens,Frank Smithuis,Paul N. Newton,Paul N. Newton,Guy E. Thwaites,Nicholas P. J. Day,Nicholas P. J. Day,Mayfong Mayxay,Mayfong Mayxay,Tran Tinh Hien,Tran Tinh Hien,François Nosten,François Nosten,Arjen M. Dondorp,Arjen M. Dondorp,Nicholas J. White,Nicholas J. White +100 more
TL;DR: The results suggest that, if used as part of a comprehensive, well-organised, and well-resourced elimination programme, dihydroartemisinin-piperaquine MDA can be a useful additional tool to accelerate malaria elimination.
Journal ArticleDOI
Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study
Mallika Imwong,Mehul Dhorda,Kyaw Myo Tun,Aung Myint Thu,Aung Pyae Phyo,Stephane Proux,Kanokon Suwannasin,Chanon Kunasol,Suttipat Srisutham,Jureeporn Duanguppama,Ranitha Vongpromek,Cholrawee Promnarate,Aungkana Saejeng,Nardlada Khantikul,Rungniran Sug-aram,Supinya Thanapongpichat,Nongyao Sawangjaroen,Kreepol Sutawong,Kay Thwe Han,Ye Htut,Khin Linn,Aye A. Win,Tin Maung Hlaing,Rob W. van der Pluijm,Rob W. van der Pluijm,Mayfong Mayxay,Mayfong Mayxay,Tiengkham Pongvongsa,Koukeo Phommasone,Rupam Tripura,Rupam Tripura,Thomas J. Peto,Thomas J. Peto,Lorenz von Seidlein,Lorenz von Seidlein,Chea Nguon,Dysoley Lek,Xin Hui S Chan,Xin Hui S Chan,Huy Rekol,Rithea Leang,Cheah Huch,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Olivo Miotto,Olivo Miotto,Olivo Miotto,Elizabeth A. Ashley,Elizabeth A. Ashley,Myat Phone Kyaw,Sasithon Pukrittayakamee,Sasithon Pukrittayakamee,Nicholas P. J. Day,Nicholas P. J. Day,Arjen M. Dondorp,Arjen M. Dondorp,Frank Smithuis,François Nosten,François Nosten,Nicholas J. White,Nicholas J. White +60 more
TL;DR: Artemisinin resistance in P falciparum is now prevalent across the Greater Mekong subregion, and in the eastern Greater Mekongs subregion a multidrug resistant P falCiparums lineage (PfPailin) dominates.
Journal ArticleDOI
HRP2: Transforming Malaria Diagnosis, but with Caveats
TL;DR: The mechanism of persistent HRP2 positivity after effective antimalarial treatment is discussed, along with other emergingHRP2-based applications, including detection of submicroscopic malaria and diagnosis of severe malaria.
Journal ArticleDOI
Resolving the cause of recurrent Plasmodium vivax malaria probabilistically
Aimee R. Taylor,Aimee R. Taylor,James A Watson,James A Watson,Cindy S. Chu,Kanokpich Puaprasert,Jureeporn Duanguppama,Nicholas P. J. Day,Nicholas P. J. Day,François Nosten,Daniel E. Neafsey,Daniel E. Neafsey,Caroline O. Buckee,Mallika Imwong,Nicholas J. White,Nicholas J. White +15 more
TL;DR: It is shown that individual vivax malaria recurrences can be characterised probabilistically by combined modelling of time-to-event and genetic data within a framework incorporating identity-by-descent and thereby demonstrate the high efficacy of primaquine treatment in preventing relapse.
References
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Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Elizabeth A. Ashley,Mehul Dhorda,Rick M. Fairhurst,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M. Anderson,Mao S,Sam B,Chantha Sopha,Char Meng Chuor,Chea Nguon,Siv Sovannaroth,Sasithon Pukrittayakamee,Podjanee Jittamala,Kesinee Chotivanich,K Chutasmit,C Suchatsoonthorn,R Runcharoen,Tran Tinh Hien,Nguyen Thuy-Nhien,Thanh Nv,Nguyen Hoan Phu,Ye Htut,Han Kt,Kyin Hla Aye,Olugbenga A. Mokuolu,Rasaq Olaosebikan,Olaleke Oluwasegun Folaranmi,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Paul N. Newton,M A Onyamboko,Caterina I. Fanello,Antoinette Tshefu,Neelima Mishra,Neena Valecha,Aung Pyae Phyo,François Nosten,Yi P,Rupam Tripura,Steffen Borrmann,Mahfudh Bashraheil,Judy Peshu,M A Faiz,Aniruddha Ghose,M A Hossain,Rasheda Samad,M. R. Rahman,Manal Hasan,Ashraful Islam,Olivo Miotto,Roberto Amato,Bronwyn MacInnis,Jim Stalker,Dominic P. Kwiatkowski,Zbynek Bozdech,Atthanee Jeeyapant,Phaik Yeong Cheah,Tharisara Sakulthaew,Jeremy Chalk,Benjamas Intharabut,Kamolrat Silamut,Lee Sj,Benchawan Vihokhern,Chanon Kunasol,Mallika Imwong,Joel Tarning,Taylor Wj,Shunmay Yeung,Charles J. Woodrow,Jennifer A. Flegg,Debashish Das,Jennifer L. Smith,Meera Venkatesan,Christopher V. Plowe,Kasia Stepniewska,Philippe J Guerin,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas J. White +82 more
TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
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Averting a malaria disaster.
Nicholas J. White,François Nosten,Sornchai Looareesuwan,William M. Watkins,Kevin Marsh,Robert W. Snow,Gilbert Kokwaro,John H. Ouma,Tran Tinh Hien,Malcolm E. Molyneux,Malcolm E. Molyneux,Terrie E. Taylor,Terrie E. Taylor,Chris I. Newbold,TK Ruebush,M Danis,Brian Greenwood,Roy M. Anderson,Piero Olliaro +18 more
TL;DR: Pyrimethamine-sulphadoxine (PSD) is usually deployed as a successor to chloroquine, but resistance to PSD is increasing and a health calamity looms within the next few years.
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Intercontinental Spread of Pyrimethamine-Resistant Malaria
TL;DR: Molecular evidence is presented demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.
Journal ArticleDOI
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker
Kyaw Myo Tun,Mallika Imwong,Khin Maung Lwin,Aye A. Win,Tin Maung Hlaing,Thaung Hlaing,Khin Lin,Myat Phone Kyaw,Katherine Plewes,Katherine Plewes,M. Abul Faiz,Mehul Dhorda,Phaik Yeong Cheah,Phaik Yeong Cheah,Sasithon Pukrittayakamee,Elizabeth A. Ashley,Elizabeth A. Ashley,Tim J. Anderson,Shalini Nair,Marina McDew-White,Jennifer A. Flegg,Eric P. M. Grist,Philippe Allard Guérin,Richard J. Maude,Richard J. Maude,Frank Smithuis,Arjen M. Dondorp,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas P. J. Day,François Nosten,Nicholas J. White,Nicholas J. White,Charles J. Woodrow,Charles J. Woodrow +34 more
TL;DR: Assessment of the spread of artemisinin-resistant P falciparum in Myanmar finds Artemisinin resistance extends across much of Myanmar, and Appropriate therapeutic regimens should be tested urgently and implemented comprehensively if spread of warfarin resistance to other regions is to be avoided.
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Spread of chloroquine resistance in Plasmodium falciparum
TL;DR: The spread of resistance to chloroquine represents a severe problem both for prophylaxis and treatment of malaria and some of its implications are discussed.
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