C
Clemencia Pinilla
Researcher at Torrey Pines Institute for Molecular Studies
Publications - 163
Citations - 11820
Clemencia Pinilla is an academic researcher from Torrey Pines Institute for Molecular Studies. The author has contributed to research in topics: Antigen & Epitope. The author has an hindex of 52, co-authored 160 publications receiving 10806 citations. Previous affiliations of Clemencia Pinilla include Florida International University & General Atomics.
Papers
More filters
Journal ArticleDOI
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
Richard A. Houghten,Clemencia Pinilla,Sylvie E. Blondelle,Jon R. Appel,Colette T. Dooley,Julio H. Cuervo +5 more
TL;DR: The precise identification of an antigenic determinant recognized by a monoclonal antibody as well as the straightforward development of new potent antimicrobial peptides are presented.
Journal ArticleDOI
The value of antimicrobial peptides in the age of resistance
Maria Magana,Muthuirulan Pushpanathan,Ana L. Santos,Leon G. Leanse,Michael Fernandez,Anastasios Ioannidis,Marc A. Giulianotti,Yiorgos Apidianakis,Steven B. Bradfute,Andrew L. Ferguson,Artem Cherkasov,Mohamed N. Seleem,Clemencia Pinilla,Cesar de la Fuente-Nunez,Themis Lazaridis,Themis Lazaridis,Tianhong Dai,Richard A. Houghten,Robert E. W. Hancock,George P. Tegos +19 more
TL;DR: The benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens are identified, advances in the deployment of novel promising antimacterial peptides are highlighted, and the needs and priorities in designing focused development strategies taking into account the most advanced tools available are underlined.
Journal ArticleDOI
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Aaron D. Schimmer,Kate Welsh,Clemencia Pinilla,Zhiliang Wang,Maryla Krajewska,Marie-Josee Bonneau,Irene M. Pedersen,Shinichi Kitada,Fiona L. Scott,Béatrice Bailly-Maitre,Gennadi V. Glinsky,Dominick Scudiero,Edward A. Sausville,Guy S. Salvesen,Adel Nefzi,John M. Ostresh,Richard A. Houghten,John C. Reed +17 more
TL;DR: An enzyme derepression assay is developed, based on overcoming XIAP-mediated suppression of Caspase-3, and mixture-based combinatorial chemical libraries are screened for compounds that reversed XI AP-mediated inhibition of Cazase- 3, identifying a class of polyphenylureas with XIAP -inhibitory activity.
Journal Article
Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.
TL;DR: A conceptually unique set of individual synthetic peptide combinatorial libraries (SPCLs) that can be used for the rapid identification of peptide sequences that bind with high affinity to antibodies, receptors or other acceptor molecules are described.
Journal ArticleDOI
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.
David Peretz,R A Williamson,Yoichi Matsunaga,Hana Serban,Clemencia Pinilla,Raiza Bastidas,Roman Rozenshteyn,Thomas L. James,Richard A. Houghten,Fred E. Cohen,Stanley B. Prusiner,Dennis R. Burton +11 more
TL;DR: It is argued from the findings that the major conformational change underlying PrPSc formation occurs within the N-terminal segment of PrP 27-30.