C
Constance Scharff
Researcher at Free University of Berlin
Publications - 84
Citations - 7168
Constance Scharff is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Zebra finch & FOXP2. The author has an hindex of 34, co-authored 81 publications receiving 6699 citations. Previous affiliations of Constance Scharff include Rockefeller University & Adelphi University.
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Journal ArticleDOI
A comparative study of the behavioral deficits following lesions of various parts of the zebra finch song system: implications for vocal learning.
TL;DR: It is concluded that Area X and LMAN contribute differently to song acquisition: the song variability that is typical of vocal development persists following early deafness or lesions of Area X but ends abruptly following removal of LMAN.
Journal ArticleDOI
The genome of a songbird
Wesley C. Warren,David F. Clayton,Hans Ellegren,Arthur P. Arnold,LaDeana W. Hillier,Axel Künstner,Steve Searle,Simon D. M. White,Albert J. Vilella,Susan Fairley,Andreas Heger,Lesheng Kong,Chris P. Ponting,Erich D. Jarvis,Claudio V. Mello,Patrick Minx,Peter V. Lovell,Tarciso A. F. Velho,Margaret Ferris,Christopher N. Balakrishnan,Saurabh Sinha,Charles Blatti,Sarah E. London,Yun Li,Ya-Chi Lin,Jimin George,Jonathan V. Sweedler,Bruce R. Southey,Preethi H. Gunaratne,Michael E. Watson,Kiwoong Nam,Niclas Backström,Linnéa Smeds,Benoit Nabholz,Yuichiro Itoh,Osceola Whitney,Andreas R. Pfenning,Jason T. Howard,Martin Völker,Benjamin M. Skinner,Darren K. Griffin,Liang Ye,William M. McLaren,Paul Flicek,Víctor Quesada,Gloria Velasco,Carlos López-Otín,Xose S. Puente,Tsviya Olender,Doron Lancet,Arian F.A. Smit,Robert Hubley,Miriam K. Konkel,Jerilyn A. Walker,Mark A. Batzer,Wanjun Gu,David D. Pollock,Lin Chen,Ze Cheng,Evan E. Eichler,Jessica Stapley,Jon Slate,Robert Ekblom,Tim R. Birkhead,Terry Burke,David W. Burt,Constance Scharff,Iris Adam,Hugues Richard,Marc Sultan,Alexey Soldatov,Hans Lehrach,Scott V. Edwards,Shiaw-Pyng Yang,XiaoChing Li,Tina Graves,Lucinda Fulton,Joanne O. Nelson,Asif T. Chinwalla,Shunfeng Hou,Elaine R. Mardis,Richard K. Wilson +81 more
TL;DR: This work shows that song behaviour engages gene regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs, transcription factors and their targets and shows evidence for rapid molecular evolution in the songbird lineage of genes that are regulated during song experience.
Journal ArticleDOI
For Whom The Bird Sings: Context-Dependent Gene Expression
TL;DR: It is shown that the anterior forebrain vocal pathway contains medial and lateral "cortical-basal ganglia" subdivisions that have differential ZENK gene activation depending on whether the bird sings female-directed or undirected song.
Journal ArticleDOI
FOXP2 as a molecular window into speech and language.
TL;DR: This body of research represents the first functional genetic forays into neural mechanisms contributing to human spoken language, and Converging data indicate that Foxp2 is important for modulating the plasticity of relevant neural circuits.
Journal ArticleDOI
Incomplete and Inaccurate Vocal Imitation after Knockdown of FoxP2 in Songbird Basal Ganglia Nucleus Area X
Sebastian Haesler,Christelle Rochefort,Christelle Rochefort,Benjamin Georgi,Pawel Licznerski,Pavel Osten,Constance Scharff,Constance Scharff +7 more
TL;DR: These findings provide the first example of a functional gene analysis in songbirds and suggest that normal auditory-guided vocal motor learning requires FoxP2, which is essential for developing the full articulatory power of human language.