Corrine Corrina R. Hartford

TL;DR: Strategies for establishing the coding potential of putative lncRNAs are discussed and various functions of known micropeptides are described to aid in diverse processes, including cell division, transcription regulation, and cell signaling.

TL;DR: It is demonstrated that FORCP is a novel, conserved small protein encoded by a mis-annotated lncRNA that regulates apoptosis and tumorigenicity in well-differentiated CRC cells.

TL;DR: Long noncoding RNAs (lncRNAs) are an increasing focus of investigation due to their implications in diverse biological processes and disease as discussed by the authors. Nevertheless, the majority of lnc RNAs are low in abunda...

TL;DR: It is shown that the endogenous FORCP transcript is rapidly degraded and rendered unstable as a result of 3’UTR-mediated degradation and the need to interrogate the function of a given 3'UTR in its native context is emphasized.

TL;DR: In this article , a p53-induced lncRNA that suppresses basal p53 levels was investigated upon p53 activation in liver cancer cells, where it is expressed at significantly higher levels than other cell types.