C
Cotton Seed
Researcher at Broad Institute
Publications - 42
Citations - 7389
Cotton Seed is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome & Khovanov homology. The author has an hindex of 19, co-authored 40 publications receiving 4013 citations. Previous affiliations of Cotton Seed include Harvard University & Intel.
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A genome-wide mutational constraint map quantified from variation in 76,156 human genomes
Siwei Chen,Laurent C. Francioli,Julia K. Goodrich,Ryan L. Collins,Qingbo Wang,Jessica Alföldi,Nicholas A. Watts,Christopher Vittal,Laura D. Gauthier,Timothy Poterba,Michael D. Wilson,Yekaterina Tarasova,William Phu,Mary T. Yohannes,Zan Koenig,Yossi Farjoun,Eric Banks,Stacey Donnelly,Stacey Gabriel,Namrata Gupta,S. K. Ferriera,Charlotte Tolonen,Sam Novod,Louis Bergelson,David Roazen,Valentin Ruano-Rubio,Miguel Covarrubias,Chris Llanwarne,Nikelle Petrillo,Gordon Wade,Thibault Jeandet,Ruchi Munshi,Kathleen Tibbetts,Anne H. O’Donnell-Luria,Matthew Solomonson,Cotton Seed,Alicia R. Martin,Michael E. Talkowski,Heidi L. Rehm,Mark J. Daly,Grace Tiao,Benjamin M. Neale,Daniel G. MacArthur,Konrad J. Karczewski +43 more
TL;DR: It is demonstrated that this genome-wide constraint map provides an effective approach for characterizing the non-coding genome and improving the identification and interpretation of functional human genetic variation.
Patent
Apparatus and method for automatically parallelizing network applications through pipelining transformation
TL;DR: In this paper, a method and apparatus for automatically parallelizing a sequential network application through pipeline transformation are described, which includes the configuration of a network processor into a D-stage processor pipeline.
Posted ContentDOI
Transcript expression-aware annotation improves rare variant discovery and interpretation
Beryl B. Cummings,Beryl B. Cummings,Konrad J. Karczewski,Konrad J. Karczewski,Jack A. Kosmicki,Jack A. Kosmicki,Eleanor G. Seaby,Eleanor G. Seaby,Nicholas A. Watts,Nicholas A. Watts,Moriel Singer-Berk,Jonathan M. Mudge,Juha Karjalainen,Juha Karjalainen,F. Kyle Satterstrom,F. Kyle Satterstrom,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,Timothy Poterba,Timothy Poterba,Cotton Seed,Cotton Seed,Matthew Solomonson,Matthew Solomonson,Jessica Alföldi,Jessica Alföldi,Mark J. Daly,Mark J. Daly,Daniel G. MacArthur,Daniel G. MacArthur +30 more
TL;DR: A transcript-level annotation metric, the proportion expressed across transcripts (pext), which summarizes isoform quantifications for variants, is developed, which clearly differentiates between weakly and highly evolutionarily conserved exons, a proxy for functional importance.
Posted ContentDOI
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries
Seyedeh M. Zekavat,Sanni Ruotsalainen,Robert E. Handsaker,Maris Alver,Jonathan M. Bloom,Tim Poterba,Cotton Seed,Jason Ernst,Mark Chaffin,Jesse M. Engreitz,Adolfo Correa,Andres Metspalu,Veikko Salomaa,Manolis Kellis,Mark J. Daly,James G. Wilson,Benjamin M. Neale,Steven A. McCarroll,Ida Surakka,Tõnu Esko,Andrea Ganna,Samuli Ripatti,Sekar Kathiresan,Pradeep Natarajan +23 more
TL;DR: In this paper, a deep-coverage whole-genome sequencing in 8,392 individuals of European and African American ancestries was performed to comprehensively delineate the inherited basis for plasma Lp(a), where apolipoprotein(a) was found to be 85% heritable among African Americans and 75% among Europeans, with notable inter-ethnic heterogeneity.
Patent
Compiler with two phase bi-directional scheduling framework for pipelined processors
TL;DR: In this paper, a method of scheduling a sequence of instructions is described, where a target program is read, a pipeline control hazard is identified within the sequence of instruction, and a selected sequence is re-ordered.