Jonathan M. Mudge

TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.

TL;DR: This work generates primary data, creates bioinformatics tools and provides analysis to support the work of expert manual gene annotators and automated gene annotation pipelines to identify and characterise gene loci to the highest standard.

TL;DR: Recent Ensembl developments are presented including two new website portals, which are designed to provide core tools and services for genomes as soon as possible and has been deployed to support large biodiversity sequencing projects.

TL;DR: The CCDS database centralizes the function of identifying well-supported, identically-annotated, protein-coding regions and indicates that the entries in the CCDS set are highly likely to represent real proteins, more so than annotations from contributing groups not included in CCDS.

TL;DR: The GENCODE project annotates human and mouse genes and transcripts supported by experimental data with high accuracy, providing a foundational resource that supports genome biology and clinical genomics as mentioned in this paper. But the annotation process does not support the creation of transcript structures and the determination of their function.