Sanni Ruotsalainen

TL;DR: The power of bottlenecked populations to find unique entry points into the biology of common diseases through low-frequency, high impact variants is demonstrated.

TL;DR: Large-scale deep-coverage whole-genome sequencing is now feasible and offers potential advantages for locus discovery and the incremental value of WGS for discovery is limited but WGS permits simultaneous assessment of monogenic and polygenic models to severe hypercholesterolemia.

TL;DR: In this article , the authors show that common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes.

TL;DR: In this paper, a multivariate logistic regression model was used to examine association between OSA and severe COVID-19 infection and showed that OSA is associated with higher body mass index (BMI), diabetes, older age and male gender.

TL;DR: This work demonstrates how sensitive the geographic patterns of current PSs are for small biases even within relatively homogeneous populations and provides simple tools to identify such biases.