C
Craig Thompson
Researcher at University of Oxford
Publications - 42
Citations - 1460
Craig Thompson is an academic researcher from University of Oxford. The author has contributed to research in topics: Vaccination & Epitope. The author has an hindex of 14, co-authored 35 publications receiving 890 citations. Previous affiliations of Craig Thompson include Medway School of Pharmacy.
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Journal ArticleDOI
The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Wanwisa Dejnirattisai,D. Zhou,Helen M. Ginn,Helen M. E. Duyvesteyn,Piyada Supasa,James Brett Case,Yuguang Zhao,Thomas S. Walter,Alexander J. Mentzer,Chang Liu,Beibei Wang,Guido C. Paesen,J Slon-Campos,Cesar Lopez-Camacho,Natasha M. Kafai,Adam L. Bailey,Rita E. Chen,Baoling Ying,Craig Thompson,Jai S Bolton,Alex Fyfe,Sunetra Gupta,Tiong Kit Tan,Javier Gilbert-Jaramillo,William James,Michael L. Knight,Miles W. Carroll,Donal T. Skelly,Christina Dold,Yanchun Peng,R Levin,Tao Dong,Andrew J. Pollard,Julian C. Knight,Paul Klenerman,Nigel J. Temperton,David R. Hall,Mark A. Williams,Neil G. Paterson,Felicity K.R. Bertram,C. Alistair Siebert,Daniel K. Clare,Andy G. Howe,Julika Radecke,Yun Song,Alain Townsend,Kuan-Ying A. Huang,Elizabeth E. Fry,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Michael S. Diamond,Jingshan Ren,David I. Stuart,Gavin R. Screaton +53 more
TL;DR: In this paper, the authors identify 377 human monoclonal antibodies (mAbs) recognizing the virus spike and focus mainly on 80 that bind the receptor binding domain (RBD) and devise a competition data-driven method to map RBD binding sites.
Posted ContentDOI
Fundamental principles of epidemic spread highlight the immediate need forlarge-scale serological surveys to assess the stage of the SARS-CoV-2 epidemic
TL;DR: The results presented here suggest the ongoing epidemics in the UK and Italy started at least a month before the first reported death and have already led to the accumulation of significant levels of herd immunity in both countries.
Journal ArticleDOI
ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice
Naif Khalaf Alharbi,Naif Khalaf Alharbi,Eriko Padron-Regalado,Craig Thompson,Alexandra Kupke,Daniel Wells,Megan A. Sloan,Keith Grehan,Nigel J. Temperton,Teresa Lambe,George M. Warimwe,Stephan Becker,Adrian V. S. Hill,Sarah C. Gilbert +13 more
TL;DR: It is shown that MERS-CoV vaccine candidates could be optimized by utilising different viral vectors, various genetic designs of the vectors, or different regimens to increase immunogenicity.
Journal ArticleDOI
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses.
Ane Ogbe,B Kronsteiner,Donal T. Skelly,M Pace,Anthony Brown,Emily Adland,Kareena Adair,H D Akhter,Mohammed Hasnat Ali,Ali S-E.,Adrienn Angyal,M A Ansari,Carolina V. Arancibia-Cárcamo,Harriet R. Brown,Senthil Chinnakannan,Christopher P. Conlon,C de Lara,T I de Silva,Christina Dold,Tao Dong,Timothy Donnison,David W Eyre,Amy Flaxman,Helen A. Fletcher,Joshua Gardner,James T. Grist,James T. Grist,Hackstein C-P.,Kanoot Jaruthamsophon,Katie Jeffery,Teresa Lambe,Lian Lee,Wenbin Li,Nicholas T.Y. Lim,Philippa C Matthews,Alexander J. Mentzer,Shona C Moore,Dean J. Naisbitt,Monday O. Ogese,Graham S. Ogg,Peter J. M. Openshaw,Munir Pirmohamed,Andrew J. Pollard,Narayan Ramamurthy,P Rongkard,P Rongkard,Sarah Rowland-Jones,Sarah Rowland-Jones,Oliver Sampson,Gavin R. Screaton,Alessandro Sette,L Stafford,Craig Thompson,Paul Thomson,Ryan S Thwaites,Virgílio Vieira,D Weiskopf,D Weiskopf,Panagiota Zacharopoulou,Lance Turtle,Paul Klenerman,P Goulder,John Frater,Eleanor Barnes,Susanna Dunachie +64 more
TL;DR: Memory responses to specific non-spike proteins provides a method to distinguish recent infection from pre-existing immunity in exposed populations using a range of T cell assays that differentially capture immune cell function.
Journal ArticleDOI
The Antigenic Anatomy of SARS-CoV-2 Receptor Binding Domain
Wanwisa Dejnirattisai,D. Zhou,Helen M. Ginn,Helen M. E. Duyvesteyn,Piyada Supasa,James Brett Case,Yuguang Zhao,Thomas S. Walter,Alexander J. Mentzer,Alexander J. Mentzer,Chang Liu,Beibei Wang,Guido C. Paesen,J Slon-Campos,Cesar Lopez-Camacho,Natasha M. Kafai,Adam L. Bailey,Rita E. Chen,Baoling Ying,Craig Thompson,Alex Fyfe,Sunetra Gupta,Tiong Kit Tan,Javier Gilbert-Jaramillo,William James,Karen R. Buttigieg,Naomi Coombes,Miles W. Carroll,Donal T. Skelly,Christina Dold,Yanchun Peng,R Levin,Tao Dong,Andrew J. Pollard,Julian C. Knight,Paul Klenerman,Nigel J. Temperton,David R. Hall,Mark A. Williams,Neil G. Paterson,Felicity K.R. Bertram,C. Alistair Seibert,Daniel K. Clare,A Howe,Julika Raedecke,Yun Song,Alain Townsend,Kuan-Ying A. Huang,Elizabeth E. Fry,Juthathip Mongkolspaya,Michael S. Diamond,Jingshan Ren,David I. Stuart,Gavin R. Screaton +53 more
TL;DR: It is shown that binding sites are widely dispersed, but neutralizing epitopes highly focused, in human monoclonal antibodies recognizing the viral spike, and by mapping antigenic sites using a unique computational methodology and comparing with inhibitory activity.