D
Dan L. Longo
Researcher at Harvard University
Publications - 730
Citations - 59268
Dan L. Longo is an academic researcher from Harvard University. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 125, co-authored 697 publications receiving 56085 citations. Previous affiliations of Dan L. Longo include University of Nebraska Omaha & Yale Cancer Center.
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Journal ArticleDOI
The Use of Molecular Profiling to Predict Survival after Chemotherapy for Diffuse Large-B-Cell Lymphoma
Andreas Rosenwald,George E. Wright,Wing C. Chan,Wing C. Chan,Joseph M. Connors,Elias Campo,Richard I. Fisher,Randy D. Gascoyne,H. Konrad Muller-Hermelink,Erlend B. Smeland,Jena M. Giltnane,Elaine M. Hurt,Hong Zhao,Lauren Averett,Liming Yang,Wyndham H. Wilson,Elaine S. Jaffe,Richard M. Simon,Richard D. Klausner,John Powell,P L Duffey,Dan L. Longo,Timothy C. Greiner,Dennis D. Weisenburger,Warren G. Sanger,Bhavana J. Dave,James C. Lynch,Julie M. Vose,James O. Armitage,Emilio Montserrat,Armando López-Guillermo,Thomas M. Grogan,Thomas P. Miller,Michel Leblanc,German Ott,Stein Kvaløy,Jan Delabie,Harald Holte,Peter Krajci,Trond Stokke,Louis M. Staudt +40 more
TL;DR: DNA microarrays can be used to formulate a molecular predictor of survival after chemotherapy for diffuse large-B-cell lymphoma and this gene-based predictor and the international prognostic index were independent prognostic indicators.
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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Julie A. Mattison,George S. Roth,T. Mark Beasley,Edward M. Tilmont,April M. Handy,April M. Handy,Richard Herbert,Dan L. Longo,David B. Allison,Jennifer E. Young,Mark Bryant,Dennis Barnard,Walter F. Ward,Wenbo Qi,Donald K. Ingram,Rafael de Cabo +15 more
TL;DR: A separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate is suggested.
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Precision Medicine — Personalized, Problematic, and Promising
J. Larry Jameson,Dan L. Longo +1 more
TL;DR: This article considers the growing recognition of precision medicine by clinicians, patients, the pharmaceutical industry, and policymakers and summarizes how this rapidly accelerating field will leave a major imprint on the practice of medicine.
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Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain
J. Raphael Gibbs,J. Raphael Gibbs,Marcel P. van der Brug,Marcel P. van der Brug,Dena G. Hernandez,Dena G. Hernandez,Bryan J. Traynor,Mike A. Nalls,Shiao Lin Lai,Shiao Lin Lai,Sampath Arepalli,Allissa Dillman,Ian Rafferty,Juan C. Troncoso,Robert Johnson,H. Ronald Zielke,Luigi Ferrucci,Dan L. Longo,Mark R. Cookson,Andrew B. Singleton +19 more
TL;DR: A set of integrated experiments that investigate the effects of common genetic variability on DNA methylation and mRNA expression in four human brain regions each from 150 individuals find an abundance of genetic cis regulation of mRNA expression and show for the first time abundant quantitative trait loci for DNA CpG methylation across the genome.
Journal ArticleDOI
Acquired Immunodeficiency Syndrome: Epidemiologic, Clinical, Immunologic, and Therapeutic Considerations
Anthony S. Fauci,Abe M. Macher,Dan L. Longo,H C Lane,Alain H. Rook,Henry Masur,Edward P. Gelmann +6 more
TL;DR: The acquired immunodeficiency syndrome is a new disease whose cause is unknown but is almost surely due to a transmissible agent, most likely a virus.