Daniel C. Factor

TL;DR: Seven drugs function at nanomolar doses selectively to enhance the generation of mature oligodendrocytes from progenitor cells in vitro and provide a rationale for testing miconazole and clobetasol, or structurally modified derivatives, to enhance remyelination in patients.

TL;DR: Direct conversion of mouse embryonic and lung fibroblasts to induced oligodendrocyte progenitor cells (iOPCs) using sets of either eight or three defined transcription factors shows a bipolar morphology and global gene expression profile consistent with bona fide OPCs.

TL;DR: A method for generating cortical spheroids from human pluripotent stem cells produces maturing oligodendrocytes that can myelinate axons and model myelin disease and drug effects and provides a versatile platform for studies of myelination of the developing central nervous system.

TL;DR: Through profiling of transcriptional enhancers, this study provides a framework for target and drug discovery in other cancers that lack known genetic drivers and are therefore difficult to treat, and reveals putative oncogenes, molecular targets and pathways.

TL;DR: A unifying sterol-based mechanism of action for most known small-molecule enhancers of oligodendrocyte formation is defined and specific targets are highlighted to propel the development of optimal remyelinating therapeutics.