C
Christopher G. Hubert
Researcher at Cleveland Clinic
Publications - 9
Citations - 1024
Christopher G. Hubert is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Cancer & In vivo. The author has an hindex of 7, co-authored 9 publications receiving 662 citations. Previous affiliations of Christopher G. Hubert include Case Western Reserve University & Cleveland Clinic Lerner College of Medicine.
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Journal ArticleDOI
Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells
David L. Schonberg,Tyler E. Miller,Qiulian Wu,William A. Flavahan,Nupur K. Das,James S. Hale,Christopher G. Hubert,Stephen C. Mack,Awad Jarrar,Robert T. Karl,Ann Mari Rosager,Anne M. Nixon,Paul J. Tesar,Petra Hamerlik,Bjarne Winther Kristensen,Craig Horbinski,James R. Connor,Paul L. Fox,Justin D. Lathia,Jeremy N. Rich +19 more
TL;DR: RNA sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing upregulation of the iron transporter transferrin, the top differentially expressed gene compared with tissue-specific progenitors, revealing an iron-regulated CSC pathway.
Journal ArticleDOI
Glioblastoma Stem Cells: Driving Resilience through Chaos.
TL;DR: Analyzing the transcriptional, epigenetic, and metabolic landscapes of GSC dynamics in the context of a stochastically fluctuating tumor network will provide novel strategies to target resistant populations of G SCs in glioblastoma.
Journal ArticleDOI
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Stephen C. Mack,Kristian W. Pajtler,Kristian W. Pajtler,Lukas Chavez,Lukas Chavez,Konstantin Okonechnikov,Kelsey C. Bertrand,Kelsey C. Bertrand,Xiuxing Wang,Xiuxing Wang,Xiuxing Wang,Serap Erkek,Alexander J. Federation,Anne Song,Anne Song,Christine Lee,Christine Lee,Xin Wang,Laura McDonald,James J. Morrow,Alina Saiakhova,Patrick Sin-Chan,Qiulian Wu,Qiulian Wu,Qiulian Wu,Kulandaimanuvel Antony Michaelraj,Tyler E. Miller,Tyler E. Miller,Christopher G. Hubert,Christopher G. Hubert,Marina Ryzhova,Livia Garzia,Laura K. Donovan,Stephen M. Dombrowski,Stephen M. Dombrowski,Daniel C. Factor,Betty Luu,Claudia L.L. Valentim,Claudia L.L. Valentim,Ryan C. Gimple,Ryan C. Gimple,Ryan C. Gimple,Andrew R. Morton,Andrew R. Morton,Leo J.Y. Kim,Leo J.Y. Kim,Leo J.Y. Kim,Briana C. Prager,Briana C. Prager,Briana C. Prager,John J.Y. Lee,Xiaochong Wu,Jennifer Zuccaro,Yuan Yao Thompson,Borja L. Holgado,Jüri Reimand,Jüri Reimand,Susan Q. Ke,Susan Q. Ke,Adam Tropper,Adam Tropper,Sisi Lai,Sisi Lai,Senthuran Vijayarajah,Senthuran Vijayarajah,Sylvia Doan,Vaidehi Mahadev,Vaidehi Mahadev,Ana Fernandez Miñan,Susanne Gröbner,Matthias Lienhard,Marc Zapatka,Zhiqin Huang,Kenneth Aldape,Angel M. Carcaboso,Peter J. Houghton,Stephen T. Keir,Till Milde,Till Milde,Hendrik Witt,Hendrik Witt,Yan Li,Chao Jun Li,Xiu-Wu Bian,David T.W. Jones,Ian C. Scott,Sheila K. Singh,Annie Huang,Annie Huang,Peter B. Dirks,Eric Bouffet,Eric Bouffet,James E. Bradner,Vijay Ramaswamy,Nada Jabado,James T. Rutka,Paul A. Northcott,Mathieu Lupien,Peter Lichter,Andrey Korshunov,Andrey Korshunov,Peter C. Scacheri,Stefan M. Pfister,Stefan M. Pfister,Marcel Kool,Michael D. Taylor,Jeremy N. Rich,Jeremy N. Rich,Jeremy N. Rich +108 more
TL;DR: Through profiling of transcriptional enhancers, this study provides a framework for target and drug discovery in other cancers that lack known genetic drivers and are therefore difficult to treat, and reveals putative oncogenes, molecular targets and pathways.
Journal ArticleDOI
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma
Tyler E. Miller,Tyler E. Miller,Brian B. Liau,Brian B. Liau,Lisa C. Wallace,Andrew R. Morton,Andrew R. Morton,Qi Xie,Deobrat Dixit,Daniel C. Factor,Leo J.Y. Kim,Leo J.Y. Kim,James J. Morrow,Qiulian Wu,Stephen C. Mack,Stephen C. Mack,Christopher G. Hubert,Christopher G. Hubert,Shawn M. Gillespie,Shawn M. Gillespie,William A. Flavahan,William A. Flavahan,Thomas Hoffmann,Rohit Thummalapalli,Rohit Thummalapalli,Michael T. Hemann,Patrick J. Paddison,Craig Horbinski,Johannes Zuber,Peter C. Scacheri,Bradley E. Bernstein,Bradley E. Bernstein,Paul J. Tesar,Jeremy N. Rich,Jeremy N. Rich,Jeremy N. Rich +35 more
TL;DR: In this article, the authors adapted pooled RNA interference (RNAi) screening technology for use in orthotopic patient-derived xenograft models, creating a high-throughput negative-selection screening platform in a functional in vivo tumour microenvironment.
Journal ArticleDOI
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma
Xiuxing Wang,Kailin Yang,Kailin Yang,Qi Xie,Qiulian Wu,Stephen C. Mack,Yu Shi,Yu Shi,Leo J.Y. Kim,Briana C. Prager,Briana C. Prager,William A. Flavahan,Xiaojing Liu,Meromit Singer,Christopher G. Hubert,Tyler E. Miller,Wenchao Zhou,Zhi Huang,Xiaoguang Fang,Aviv Regev,Mario L. Suvà,Mario L. Suvà,Tae Hyun Hwang,Jason W. Locasale,Shideng Bao,Jeremy N. Rich,Jeremy N. Rich +26 more
TL;DR: Wang et al. as mentioned in this paper reported that de novo purine biosynthesis reprograms BTIC metabolism, revealing a potential point of fragility amenable to targeted cancer therapy.