S
Susanne Gröbner
Researcher at German Cancer Research Center
Publications - 17
Citations - 3055
Susanne Gröbner is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Medulloblastoma & Cancer. The author has an hindex of 12, co-authored 15 publications receiving 2130 citations. Previous affiliations of Susanne Gröbner include Heidelberg University.
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Journal ArticleDOI
The landscape of genomic alterations across childhood cancers
Susanne Gröbner,Barbara C. Worst,Joachim Weischenfeldt,Joachim Weischenfeldt,Ivo Buchhalter,Kortine Kleinheinz,Vasilisa A. Rudneva,Pascal Johann,Gnana Prakash Balasubramanian,Maia Segura-Wang,Sebastian Brabetz,Sebastian Bender,Barbara Hutter,Dominik Sturm,Elke Pfaff,Daniel Hübschmann,Gideon Zipprich,Michael Heinold,Michael Heinold,Jürgen Eils,Christian Lawerenz,Serap Erkek,Sander Lambo,Sebastian M. Waszak,Claudia Blattmann,Arndt Borkhardt,Arndt Borkhardt,Michaela Kuhlen,Michaela Kuhlen,Angelika Eggert,Angelika Eggert,Simone Fulda,Manfred Gessler,Jenny Wegert,Roland Kappler,Roland Kappler,Daniel Baumhoer,Stefan Burdach,Stefan Burdach,Renate Kirschner-Schwabe,Renate Kirschner-Schwabe,Udo Kontny,Andreas E. Kulozik,Andreas E. Kulozik,Dietmar R. Lohmann,Simone Hettmer,Cornelia Eckert,Cornelia Eckert,Stefan S. Bielack,Michaela Nathrath,Michaela Nathrath,Charlotte M. Niemeyer,Charlotte M. Niemeyer,Gunther Richter,Gunther Richter,Johannes H. Schulte,Johannes H. Schulte,Reiner Siebert,Frank Westermann,Jan J. Molenaar,Gilles Vassal,Hendrik Witt,Peter Lichter,Ursula Weber,Roland Eils,Roland Eils,Andrey Korshunov,Olaf Witt,Stefan Pfister,Guido Reifenberger,J Felsberg,Christof von Kalle,Manfred Schmidt,Cynthia Bartholomä,Michael Taylor,David T. W. Jones,Natalie Jäger,Korbel Jo,Adrian M. Stütz,Tobias Rausch,Bernhard Radlwimmer,Marie-Laure Yaspo,Hans Lehrach,Hans-Jörg Warnatz,Pablo Landgraf,Benedikt Brors,Marc Zapatka,Marc Zapatka,Susanne Wagner,Susanne Wagner,Andrea Haake,Julia Richter,Gesine Richter,Gesine Richter,Chris Lawerenz,Jules Kerssemakers,Christina Jaeger-Schmidt,Ingrid Scholz,Anke K. Bergmann,Christoph Borst,Birgit Burkhardt,Alexander Claviez,Martin Dreyling,Martin Dreyling,Sonja Eberth,Hermann Einsele,Norbert Frickhofen,Siegfried Haas,Martin-Leo Hansmann,Dennis Karsch,Michael Kneba,Jasmin Lisfeld,Luisa Mantovani-Löffler,Marius Rohde,German Ott,Christina Stadler,Peter Staib,Stephan Stilgenbauer,Lorenz Trümper,Thorsten Zenz,Dieter Kube,Ralf Küppers,Marc A. Weniger,Michael Hummel,Wolfram Klapper,Ulrike Kostezka,Dido Lenze,Peter Möller,Andreas Rosenwald,Monika Szczepanowski,Ole Ammerpohl,Sietse M. Aukema,Vera Binder,Jessica I. Hoell,Ellen Leich,Cristina López,Inga Nagel,Jordan Pischimariov,Philip Rosenstiel,Markus Schilhabel,Stefan Schreiber,Inga Vater,Rabea Wagener,Stephan H. Bernhart,Hans Binder,Gero Doose,Steve Hoffmann,Lydia Hopp,Helene Kretzmer,Markus Kreuz,David Langenberger,Markus Loeffler,Maciej Rosolowski,Matthias Schlesner,Peter F. Stadler,Stephanie Sungalee,Christian P. Kratz,Cornelis M. van Tilburg,Christof M. Kramm,Gudrun Fleischhack,Gudrun Fleischhack,Uta Dirksen,Stefan Rutkowski,Michael C. Frühwald,Katja von Hoff,Stephan Wolf,Thomas Klingebiel,Thomas Klingebiel,Ewa Koscielniak,Jan Koster,Adam C. Resnick,Jinghui Zhang,Yanling Liu,Xin Zhou,Angela J. Waanders,Danny A. Zwijnenburg,Pichai Raman,Ursula D. Weber,Paul A. Northcott,Kristian W. Pajtler,Marcel Kool,Rosario M. Piro,Jan O. Korbel,David T.W. Jones,Lukas Chavez,Stefan M. Pfister +185 more
TL;DR: The data suggest that 7–8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.
Journal ArticleDOI
The whole-genome landscape of medulloblastoma subtypes
Paul A. Northcott,Paul A. Northcott,Ivo Buchhalter,Ivo Buchhalter,A. Sorana Morrissy,Volker Hovestadt,Joachim Weischenfeldt,Tobias Ehrenberger,Susanne Gröbner,Maia Segura-Wang,Thomas Zichner,Vasilisa A. Rudneva,Hans-Jörg Warnatz,Nikos Sidiropoulos,Aaron H. Phillips,Steven E. Schumacher,Kortine Kleinheinz,Sebastian M. Waszak,Serap Erkek,Serap Erkek,David T.W. Jones,Barbara C. Worst,Marcel Kool,Marc Zapatka,Natalie Jäger,Lukas Chavez,Barbara Hutter,Matthias Bieg,Nagarajan Paramasivam,Nagarajan Paramasivam,Michael Heinold,Michael Heinold,Zuguang Gu,Naveed Ishaque,Christina Jäger-Schmidt,Charles D. Imbusch,Alke Jugold,Daniel Hübschmann,Daniel Hübschmann,Daniel Hübschmann,Thomas Risch,Vyacheslav Amstislavskiy,Francisco German Rodriguez Gonzalez,Ursula D. Weber,Stephan Wolf,Giles W. Robinson,Xin Zhou,Gang Wu,David Finkelstein,Yanling Liu,Florence M.G. Cavalli,Betty Luu,Vijay Ramaswamy,Xiaochong Wu,Jan Koster,Marina Ryzhova,Yoon Jae Cho,Scott L. Pomeroy,Christel Herold-Mende,Martin U. Schuhmann,Martin Ebinger,Linda M. Liau,Jaume Mora,Roger E. McLendon,Nada Jabado,Toshihiro Kumabe,Eric Chuah,Yussanne Ma,Richard A. Moore,Andrew J. Mungall,Karen Mungall,Nina Thiessen,Kane Tse,Tina Wong,Steven J.M. Jones,Olaf Witt,Till Milde,Andreas von Deimling,David Capper,Andrey Korshunov,Marie-Laure Yaspo,Richard W. Kriwacki,Amar Gajjar,Jinghui Zhang,Rameen Beroukhim,Ernest Fraenkel,Jan O. Korbel,Benedikt Brors,Matthias Schlesner,Roland Eils,Roland Eils,Marco A. Marra,Stefan M. Pfister,Stefan M. Pfister,Michael D. Taylor,Peter Lichter +95 more
TL;DR: The application of integrative genomics to an extensive cohort of clinical samples derived from a single childhood cancer entity revealed a series of cancer genes and biologically relevant subtype diversity that represent attractive therapeutic targets for the treatment of patients with medulloblastoma.
Journal ArticleDOI
Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes
Pascal Johann,Pascal Johann,Serap Erkek,Marc Zapatka,Kornelius Kerl,Ivo Buchhalter,Volker Hovestadt,David T.W. Jones,Dominik Sturm,Dominik Sturm,Carl Hermann,Maia Segura Wang,Andrey Korshunov,Andrey Korshunov,Marina Rhyzova,Susanne Gröbner,Sebastian Brabetz,Lukas Chavez,Susanne Bens,Stefan Gröschel,Fabian Kratochwil,Andrea Wittmann,Laura Sieber,Christina Geörg,Stefan Wolf,Katja Beck,Florian Oyen,David Capper,David Capper,Peter van Sluis,Richard Volckmann,Jan Koster,Rogier Versteeg,Andreas von Deimling,Andreas von Deimling,Till Milde,Till Milde,Olaf Witt,Olaf Witt,Andreas E. Kulozik,Martin Ebinger,Tarek Shalaby,Michael A. Grotzer,David Sumerauer,Josef Zamecnik,Jaume Mora,Nada Jabado,Michael D. Taylor,Annie Huang,Eleonora Aronica,Anna Marta Maria Bertoni,Bernhard Radlwimmer,Torsten Pietsch,Ulrich Schüller,Reinhard Schneppenheim,Paul A. Northcott,Jan O. Korbel,Reiner Siebert,Michael C. Frühwald,Michael C. Frühwald,Peter Lichter,Roland Eils,Amar Gajjar,Martin Hasselblatt,Stefan M. Pfister,Stefan M. Pfister,Marcel Kool +66 more
TL;DR: Three distinct molecular subgroups of ATRTs, associated with differences in demographics, tumor location, and type of SMARCB1 alterations, were identified, leading to the identification of subgroup-specific regulatory networks and potential therapeutic targets.
Journal ArticleDOI
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
Tyler Alioto,Ivo Buchhalter,Sophia Derdak,Barbara Hutter,Matthew D. Eldridge,Eivind Hovig,Lawrence E. Heisler,Timothy Beck,Jared T. Simpson,Laurie Tonon,Anne Sophie Sertier,Ann-Marie Patch,Ann-Marie Patch,Natalie Jäger,Natalie Jäger,Philip Ginsbach,Ruben M. Drews,Nagarajan Paramasivam,Rolf Kabbe,Sasithorn Chotewutmontri,Nicolle Diessl,Christopher Previti,Sabine Schmidt,Benedikt Brors,Lars Feuerbach,Michael Heinold,Susanne Gröbner,Andrey Korshunov,Patrick S. Tarpey,Adam Butler,Jonathan Hinton,David T. Jones,Andrew Menzies,Keiran Raine,Rebecca Shepherd,Lucy Stebbings,Jon W. Teague,Paolo Ribeca,Francesc Castro Giner,Sergi Beltran,Emanuele Raineri,Marc Dabad,Simon Heath,Marta Gut,Robert E. Denroche,Nicholas J. Harding,Takafumi N. Yamaguchi,Akihiro Fujimoto,Hidewaki Nakagawa,Víctor Quesada,Rafael Valdés-Mas,Sigve Nakken,Daniel Vodak,Lawrence Bower,Andy G. Lynch,Charlotte Anderson,Charlotte Anderson,Nicola Waddell,Nicola Waddell,John V. Pearson,John V. Pearson,Sean M. Grimmond,Sean M. Grimmond,Myron Peto,Paul T. Spellman,Minghui He,Cyriac Kandoth,Semin Lee,John Zhang,John Zhang,Louis Letourneau,Singer Ma,Sahil Seth,David Torrents,Liu Xi,David A. Wheeler,Carlos López-Otín,Elias Campo,Peter J. Campbell,Paul C. Boutros,Xose S. Puente,Daniela S. Gerhard,Stefan M. Pfister,Stefan M. Pfister,John Douglas Mcpherson,John Douglas Mcpherson,Thomas J. Hudson,Thomas J. Hudson,Matthias Schlesner,Peter Lichter,Roland Eils,Roland Eils,David T. W. Jones,Ivo Gut +93 more
TL;DR: It is shown that using PCR-free methods and increasing sequencing depth to ∼100 × shows benefits, as long as the tumour:control coverage ratio remains balanced, and many issues are in fact easy to remedy and have an immediate positive impact on mutation detection accuracy.
Journal ArticleDOI
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Stephen C. Mack,Kristian W. Pajtler,Kristian W. Pajtler,Lukas Chavez,Lukas Chavez,Konstantin Okonechnikov,Kelsey C. Bertrand,Kelsey C. Bertrand,Xiuxing Wang,Xiuxing Wang,Xiuxing Wang,Serap Erkek,Alexander J. Federation,Anne Song,Anne Song,Christine Lee,Christine Lee,Xin Wang,Laura McDonald,James J. Morrow,Alina Saiakhova,Patrick Sin-Chan,Qiulian Wu,Qiulian Wu,Qiulian Wu,Kulandaimanuvel Antony Michaelraj,Tyler E. Miller,Tyler E. Miller,Christopher G. Hubert,Christopher G. Hubert,Marina Ryzhova,Livia Garzia,Laura K. Donovan,Stephen M. Dombrowski,Stephen M. Dombrowski,Daniel C. Factor,Betty Luu,Claudia L.L. Valentim,Claudia L.L. Valentim,Ryan C. Gimple,Ryan C. Gimple,Ryan C. Gimple,Andrew R. Morton,Andrew R. Morton,Leo J.Y. Kim,Leo J.Y. Kim,Leo J.Y. Kim,Briana C. Prager,Briana C. Prager,Briana C. Prager,John J.Y. Lee,Xiaochong Wu,Jennifer Zuccaro,Yuan Yao Thompson,Borja L. Holgado,Jüri Reimand,Jüri Reimand,Susan Q. Ke,Susan Q. Ke,Adam Tropper,Adam Tropper,Sisi Lai,Sisi Lai,Senthuran Vijayarajah,Senthuran Vijayarajah,Sylvia Doan,Vaidehi Mahadev,Vaidehi Mahadev,Ana Fernandez Miñan,Susanne Gröbner,Matthias Lienhard,Marc Zapatka,Zhiqin Huang,Kenneth Aldape,Angel M. Carcaboso,Peter J. Houghton,Stephen T. Keir,Till Milde,Till Milde,Hendrik Witt,Hendrik Witt,Yan Li,Chao Jun Li,Xiu-Wu Bian,David T.W. Jones,Ian C. Scott,Sheila K. Singh,Annie Huang,Annie Huang,Peter B. Dirks,Eric Bouffet,Eric Bouffet,James E. Bradner,Vijay Ramaswamy,Nada Jabado,James T. Rutka,Paul A. Northcott,Mathieu Lupien,Peter Lichter,Andrey Korshunov,Andrey Korshunov,Peter C. Scacheri,Stefan M. Pfister,Stefan M. Pfister,Marcel Kool,Michael D. Taylor,Jeremy N. Rich,Jeremy N. Rich,Jeremy N. Rich +108 more
TL;DR: Through profiling of transcriptional enhancers, this study provides a framework for target and drug discovery in other cancers that lack known genetic drivers and are therefore difficult to treat, and reveals putative oncogenes, molecular targets and pathways.