D
David A. Hinds
Researcher at UCL Institute of Neurology
Publications - 6
Citations - 383
David A. Hinds is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Genome-wide association study & Genetic association. The author has an hindex of 5, co-authored 6 publications receiving 193 citations.
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Journal ArticleDOI
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.
Cornelis Blauwendraat,Karl Heilbron,Costanza L. Vallerga,Sara Bandres-Ciga,Rainer von Coelln,Lasse Pihlstrøm,Javier Simón-Sánchez,Javier Simón-Sánchez,Claudia Schulte,Claudia Schulte,Manu Sharma,Lynne Krohn,Lynne Krohn,Ari Siitonen,Ari Siitonen,Hirotaka Iwaki,Hirotaka Iwaki,Hampton L. Leonard,Alastair J. Noyce,Alastair J. Noyce,Manuela Tan,J. Raphael Gibbs,Dena G. Hernandez,Sonja W. Scholz,Joseph Jankovic,Lisa M. Shulman,Suzanne Lesage,Jean-Christophe Corvol,Alexis Brice,Jacobus J. van Hilten,Johan Marinus,Johanna Eerola-Rautio,Pentti J. Tienari,Kari Majamaa,Mathias Toft,Mathias Toft,Donald G. Grosset,Donald G. Grosset,Thomas Gasser,Peter Heutink,Peter Heutink,Joshua M. Shulman,Joshua M. Shulman,N Wood,N Wood,John Hardy,Huw R. Morris,David A. Hinds,Jacob Gratten,Peter M. Visscher,Peter M. Visscher,Ziv Gan-Or,Mike A. Nalls,Mike A. Nalls,Andrew B. Singleton +54 more
TL;DR: The genetic determinants of PD age at onset are largely unknown and increasing evidence supports an extensive and complex genetic contribution to PD.
Journal ArticleDOI
The Parkinson's Disease Mendelian Randomization Research Portal
Alastair J. Noyce,Alastair J. Noyce,Sara Bandres-Ciga,Sara Bandres-Ciga,Jonggeol J. Kim,Karl Heilbron,Demis A. Kia,Gibran Hemani,Angli Xue,Debbie A Lawlor,G Davey Smith,Raquel Duran,Ziv Gan-Or,Ziv Gan-Or,Cornelis Blauwendraat,Raphael Gibbs,David A. Hinds,Jian Yang,Peter M. Visscher,Peter M. Visscher,Jack Cuzick,Huw R. Morris,John Hardy,N Wood,Mike A. Nalls,Andrew B. Singleton +25 more
TL;DR: Mendelian randomization is a method for exploring observational associations to find evidence of causality in order to explore patterns in natural disasters.
Posted ContentDOI
Resource Profile and User Guide of the Polygenic Index Repository
Joel Becker,Casper A.P. Burik,Grant Goldman,Nancy Wang,Hariharan Jayashankar,Michael Bennett,Daniel W. Belsky,Richard Karlsson Linnér,Rafael Ahlskog,Aaron Kleinman,David A. Hinds,Avshalom Caspi,David L. Corcoran,Terrie E. Moffitt,Richie Poulton,Karen Sugden,Benjamin Williams,Kathleen Mullan Harris,Andrew Steptoe,Olesya Ajnakina,Olesya Ajnakina,Lili Milani,Tõnu Esko,Tõnu Esko,William G. Iacono,Matt McGue,Patrik K. E. Magnusson,Travis T. Mallard,K. Paige Harden,Elliot M. Tucker-Drob,Pamela Herd,Jeremy Freese,Alexander I. Young,Jonathan P. Beauchamp,Philipp Koellinger,Philipp Koellinger,Sven Oskarsson,Magnus Johannesson,Peter M. Visscher,Michelle N. Meyer,David Laibson,David Laibson,David Cesarini,David Cesarini,Daniel J. Benjamin,Daniel J. Benjamin,Patrick Turley,Patrick Turley,Aysu Okbay +48 more
TL;DR: A theoretical framework is presented to help interpret analyses involving PGIs and it is revealed that a PGI can be understood as an unbiased but noisy measure of a latent variable the authors call the “additive SNP factor.”
Journal ArticleDOI
Resource profile and user guide of the Polygenic Index Repository.
Joel Becker,Casper A.P. Burik,Grant Goldman,Nancy Wang,Hariharan Jayashankar,Michael Bennett,Daniel W. Belsky,Richard Karlsson Linnér,Rafael Ahlskog,Aaron Kleinman,David A. Hinds,Avshalom Caspi,David L. Corcoran,Terrie E. Moffitt,Richie Poulton,Karen Sugden,Benjamin Williams,Kathleen Mullan Harris,Andrew Steptoe,Olesya Ajnakina,Olesya Ajnakina,Lili Milani,Tõnu Esko,Tõnu Esko,William G. Iacono,Matt McGue,Patrik K. E. Magnusson,Travis T. Mallard,K. Paige Harden,Elliot M. Tucker-Drob,Pamela Herd,Jeremy Freese,Alexander I. Young,Jonathan P. Beauchamp,Philipp Koellinger,Philipp Koellinger,Sven Oskarsson,Magnus Johannesson,Peter M. Visscher,Michelle N. Meyer,David Laibson,David Laibson,David Cesarini,David Cesarini,Daniel J. Benjamin,Daniel J. Benjamin,Patrick Turley,Aysu Okbay +47 more
TL;DR: In this article, the additive SNP factor was used as a proxy for the PGI to correct the errors-in-variables bias in the regression model, and an estimator that corrects the bias was presented.
Posted ContentDOI
Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms
Cornelis Blauwendraat,Karl Heilbron,Costanza L. Vallerga,Sara Bandres-Ciga,Rainer von Coelln,Lasse Pihlstrøm,Javier Simón-Sánchez,Javier Simón-Sánchez,Claudia Schulte,Claudia Schulte,Manu Sharma,Lynne Krohn,Lynne Krohn,Ari Siitonen,Ari Siitonen,Hirotaka Iwaki,Hirotaka Iwaki,Hampton L. Leonard,Alastair J. Noyce,Alastair J. Noyce,Manuela Tan,J. Raphael Gibbs,Dena G. Hernandez,Sonja W. Scholz,Joseph Jankovic,Lisa M. Shulman,Suzanne Lesage,Jean-Christophe Corvol,Alexis Brice,Jacobus J. van Hilten,Johan Marinus,Pentti J. Tienari,Pentti J. Tienari,Kari Majamaa,Kari Majamaa,Mathias Toft,Mathias Toft,Donald G. Grosset,Thomas Gasser,Thomas Gasser,Peter Heutink,Peter Heutink,Joshua M. Shulman,Joshua M. Shulman,N Wood,John Hardy,Huw R. Morris,David A. Hinds,Jacob Gratten,Peter M. Visscher,Ziv Gan-Or,Ziv Gan-Or,Mike A. Nalls,Andrew B. Singleton +53 more
TL;DR: An age of onset GWAS based on 28,568 Parkinson’s disease cases shows a model in which alpha-synuclein and lysosomal mechanisms impact not only PD risk but also age of disease onset and highlights that therapies that target alpha- synuclein aggregation are more likely to be disease-modifying than therapies targeting other pathways.