C
Casper A.P. Burik
Researcher at VU University Amsterdam
Publications - 12
Citations - 650
Casper A.P. Burik is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Instrumental variable & Lottery. The author has an hindex of 6, co-authored 12 publications receiving 469 citations. Previous affiliations of Casper A.P. Burik include Erasmus University Rotterdam & Tinbergen Institute.
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Journal ArticleDOI
Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia
Vikas Bansal,Marina Mitjans,Casper A.P. Burik,Casper A.P. Burik,Richard Karlsson Linnér,Richard Karlsson Linnér,Aysu Okbay,Cornelius A. Rietveld,Martin Begemann,Stefan Bonn,Stefan Bonn,Stephan Ripke,Stephan Ripke,Stephan Ripke,Ronald de Vlaming,Michel G. Nivard,Hannelore Ehrenreich,Philipp Koellinger,Philipp Koellinger +18 more
TL;DR: Strong genetic dependence between EA and SZ is found that cannot be explained by chance, linkage disequilibrium, or assortative mating, and multiple genes have pleiotropic effects on both without a systematic pattern of sign concordance.
Journal ArticleDOI
Genomic analysis of diet composition finds novel loci and associations with health and lifestyle.
S. Fleur W. Meddens,S. Fleur W. Meddens,Ronald de Vlaming,Peter Bowers,Casper A.P. Burik,Richard Karlsson Linnér,Chanwook Lee,Aysu Okbay,Patrick Turley,Patrick Turley,Patrick Turley,Cornelius A. Rietveld,Mark Alan Fontana,Mark Alan Fontana,Mohsen Ghanbari,Mohsen Ghanbari,Fumiaki Imamura,George McMahon,Peter J. van der Most,Trudy Voortman,Kaitlin H Wade,Emma L Anderson,Kim Valeska Emilie Braun,Pauline M Emmett,Tonũ Esko,Juan R. González,Jessica C. Kiefte-de Jong,Jessica C. Kiefte-de Jong,Claudia Langenberg,Jian'an Luan,Taulant Muka,Susan M. Ring,Fernando Rivadeneira,Harold Snieder,Frank J. A. van Rooij,Bruce H. R. Wolffenbuttel,George Davey Smith,Oscar H. Franco,Nita G. Forouhi,M. Arfan Ikram,André G. Uitterlinden,Jana V. van Vliet-Ostaptchouk,Nicholas J. Wareham,David Cesarini,K. Paige Harden,James J. Lee,Daniel J. Benjamin,Daniel J. Benjamin,Carson C. Chow,Philipp Koellinger +49 more
TL;DR: The results are consistent with the hypothesis that relative protein intake plays a role in the etiology of metabolic dysfunction, and no evidence of negative health consequences associated with relative carbohydrate, sugar, or fat intake is found.
Journal ArticleDOI
Genetic instrumental variable regression: Explaining socioeconomic and health outcomes in nonexperimental data
TL;DR: The performance of GIV regression in the presence of pleiotropy across a range of scenarios is explored and it is found that it yields more accurate estimates than alternative approaches such as ordinary least-squares regression or Mendelian randomization.
Posted ContentDOI
Resource Profile and User Guide of the Polygenic Index Repository
Joel Becker,Casper A.P. Burik,Grant Goldman,Nancy Wang,Hariharan Jayashankar,Michael Bennett,Daniel W. Belsky,Richard Karlsson Linnér,Rafael Ahlskog,Aaron Kleinman,David A. Hinds,Avshalom Caspi,David L. Corcoran,Terrie E. Moffitt,Richie Poulton,Karen Sugden,Benjamin Williams,Kathleen Mullan Harris,Andrew Steptoe,Olesya Ajnakina,Olesya Ajnakina,Lili Milani,Tõnu Esko,Tõnu Esko,William G. Iacono,Matt McGue,Patrik K. E. Magnusson,Travis T. Mallard,K. Paige Harden,Elliot M. Tucker-Drob,Pamela Herd,Jeremy Freese,Alexander I. Young,Jonathan P. Beauchamp,Philipp Koellinger,Philipp Koellinger,Sven Oskarsson,Magnus Johannesson,Peter M. Visscher,Michelle N. Meyer,David Laibson,David Laibson,David Cesarini,David Cesarini,Daniel J. Benjamin,Daniel J. Benjamin,Patrick Turley,Patrick Turley,Aysu Okbay +48 more
TL;DR: A theoretical framework is presented to help interpret analyses involving PGIs and it is revealed that a PGI can be understood as an unbiased but noisy measure of a latent variable the authors call the “additive SNP factor.”
Journal ArticleDOI
Resource profile and user guide of the Polygenic Index Repository.
Joel Becker,Casper A.P. Burik,Grant Goldman,Nancy Wang,Hariharan Jayashankar,Michael Bennett,Daniel W. Belsky,Richard Karlsson Linnér,Rafael Ahlskog,Aaron Kleinman,David A. Hinds,Avshalom Caspi,David L. Corcoran,Terrie E. Moffitt,Richie Poulton,Karen Sugden,Benjamin Williams,Kathleen Mullan Harris,Andrew Steptoe,Olesya Ajnakina,Olesya Ajnakina,Lili Milani,Tõnu Esko,Tõnu Esko,William G. Iacono,Matt McGue,Patrik K. E. Magnusson,Travis T. Mallard,K. Paige Harden,Elliot M. Tucker-Drob,Pamela Herd,Jeremy Freese,Alexander I. Young,Jonathan P. Beauchamp,Philipp Koellinger,Philipp Koellinger,Sven Oskarsson,Magnus Johannesson,Peter M. Visscher,Michelle N. Meyer,David Laibson,David Laibson,David Cesarini,David Cesarini,Daniel J. Benjamin,Daniel J. Benjamin,Patrick Turley,Aysu Okbay +47 more
TL;DR: In this article, the additive SNP factor was used as a proxy for the PGI to correct the errors-in-variables bias in the regression model, and an estimator that corrects the bias was presented.