D
David A. Jaffe
Researcher at University of California, Davis
Publications - 11
Citations - 194
David A. Jaffe is an academic researcher from University of California, Davis. The author has contributed to research in topics: Bartonella & Bartonella Infection. The author has an hindex of 5, co-authored 9 publications receiving 90 citations.
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Journal ArticleDOI
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.
Elizabeth K. Unger,Jacob P. Keller,Michael Altermatt,Ruqiang Liang,Aya Matsui,Chunyang Dong,Olivia J Hon,Zi Yao,Junqing Sun,Samba Banala,Meghan E. Flanigan,David A. Jaffe,Samantha Hartanto,Jane Carlen,Grace O. Mizuno,Phillip M. Borden,Amol V. Shivange,Lindsay P. Cameron,Steffen Sinning,Suzanne M. Underhill,David E. Olson,Susan G. Amara,Duncan Temple Lang,Gary Rudnick,Jonathan S. Marvin,Luke D. Lavis,Henry A. Lester,Veronica A. Alvarez,Andrew J. Fisher,Jennifer A. Prescher,Thomas L. Kash,Vladimir Yarov-Yarovoy,Viviana Gradinaru,Loren L. Looger,Lin Tian +34 more
TL;DR: iSeroSnFR can be used to detect serotonin release in freely behaving mice during fear conditioning, social interaction, and sleep/wake transitions, and it is expected that both machine-learning-guided binding-pocket redesign and iSero SnFR will have broad utility for the development of other sensors and in vitro and in-vivo serotonin detection, respectively.
Journal ArticleDOI
Directed Evolution of a Selective and Sensitive Serotonin Biosensor Via Machine Learning
Elizabeth K. Unger,Jacob P. Keller,Michael Altermatt,Ruqiang Liang,Zi Yao,Junqing Sun,Aya Matsui,Chunyang Dong,David A. Jaffe,Samantha Hartanto,Grace O. Mizuno,Phillip M. Borden,Amol V. Shivange,Steffen Sinning,Suzanne M. Underhill,Jane Carlin,Samba Banala,Lindsay P. Cameron,David E. Olson,Susan G. Amara,Duncan Temple Lang,Gary Rudnick,Jonathan S. Marvin,Luke D. Lavis,Henry A. Lester,Veronica A. Alvarez,Andrew J. Fisher,Jennifer A. Prescher,Vladimir Yarov-Yarovoy,Viviana Gradinaru,Loren L. Looger,Lin Tian +31 more
TL;DR: In this paper, a binding pocket redesign strategy guided by machine learning is used to create a high-performance soluble, fluorescent serotonin sensor (iSeroSnFR), which has sufficient selectivity and sensitivity needed for direct detection of serotonin transients in various biological systems, especially permits detection of subsecondscale serotonin release events during fear conditioning and sleep-to-wakefulness transitions.
Journal ArticleDOI
Bartonella henselae in small Indian mongooses (Herpestes auropunctatus) from Grenada, West Indies
David A. Jaffe,Bruno B Chomel,Rickie W. Kasten,Edward B. Breitschwerdt,Ricardo G. Maggi,Ashleigh McLeish,Ulrike Zieger +6 more
TL;DR: The role of small Indian mongooses as a natural reservoir of B. henselae in the New World is confirmed and documented to identify a potential source of zoonotic risk with mongoose-human contact in theNew World.
Journal ArticleDOI
Molecular Detection of Bartonella Species in Blood-Feeding Bat Flies from Mexico.
Alexandra E Moskaluk,Matthew J. Stuckey,David A. Jaffe,Rickie W. Kasten,Alvaro Aguilar-Setién,José Ignacio Olave-Leyva,Guillermo Galvez-Romero,Cirani Obregón-Morales,Mónica Salas-Rojas,María Martha García-Flores,Nidia Aréchiga-Ceballos,Anahí García-Baltazar,Bruno B Chomel +12 more
TL;DR: Investigating the relatedness between Bartonella detected or isolated from bat hosts sampled in Mexico and their ectoparasites suggested a possible endosymbiotic relationship with these vectors for some of the Bartonellae species carried by bat flies, whereas others could have a mammalian host.
Journal ArticleDOI
Detection of Bartonella species, including Candidatus Bartonella ovis sp. nov, in ruminants from Mexico and lack of evidence of Bartonella DNA in saliva of common vampire bats (Desmodus rotundus) predating on them.
Adam P. Raya,David A. Jaffe,Bruno B Chomel,Marissa S. Ota,Peter M. Tsou,Aaron Z. Davis,José Ignacio Olave-Leyva,Guillermo Galvez-Romero,Matthew J. Stuckey,Rickie W. Kasten,Cirani Obregón-Morales,Nidia Aréchiga-Ceballos,Flor Olivia Martínez-Martínez,Alvaro Aguilar-Setién +13 more
TL;DR: This study does not support the role of D. rotundus as a reservoir of Bartonella species infecting livestock, which could be transmitted via bite and blood feeding and therefore suggest limited risk of zoonotic transmission of Bart onella from common vampire bats to humans.