Grace O. Mizuno

TL;DR: Red-shifted variants of dopamine sensors called RdLight1 are engineered, based on mApple, and revealed that dopamine release in the nucleus accumbens evoked by reward-predictive cues is accompanied by a rapid suppression of glutamate release.

TL;DR: iSeroSnFR can be used to detect serotonin release in freely behaving mice during fear conditioning, social interaction, and sleep/wake transitions, and it is expected that both machine-learning-guided binding-pocket redesign and iSero SnFR will have broad utility for the development of other sensors and in vitro and in-vivo serotonin detection, respectively.

TL;DR: This study identified neural circuits underlying thirst satiation and examined their contribution to reward signals, showing that thirst-driving neurons receive temporally distinct satiation signals by liquid-gulping-induced oropharyngeal stimuli and gut osmolality sensing and demonstrates that individual thirst satiated signals are mediated by anatomically distinct inhibitory neural circuits in the lamina terminalis.

TL;DR: The results suggest a mechanism by which DS alters the function of astrocytes, which subsequently disturbs neuronal excitability, and suppressed neuronal activity could be rescued.

TL;DR: This paper found that acute morphine withdrawal evokes dynorphin release in the medial prefrontal cortex (PFC) and disrupts cognitive function by activation of local kappa opioid receptors (KORs).