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David Enot
Researcher at Institut Gustave Roussy
Publications - 80
Citations - 11106
David Enot is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Immune system & Immunosurveillance. The author has an hindex of 41, co-authored 80 publications receiving 8718 citations. Previous affiliations of David Enot include University of Paris-Sud & Aberystwyth University.
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Journal ArticleDOI
Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs.
Rønnaug Solberg,David Enot,Hans-Peter Deigner,Therese Koal,Sabine Scholl-Bürgi,Ola Didrik Saugstad,Matthias Keller +6 more
TL;DR: This study provides a novel strategy and set of biomarkers that provide biochemical in vivo data that resuscitation with 100% oxygen delays cellular recovery and raises concerns about the safety of 100% O2 resuscitation.
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Rice blast infection of Brachypodium distachyon as a model system to study dynamic host/pathogen interactions
David A. Parker,Manfred Beckmann,David Enot,David P. Overy,Zaira Caracuel Rios,Martin J. Gilbert,Nicholas J. Talbot,John Draper +7 more
TL;DR: The use of metabolite fingerprinting and multivariate data analysis to assess disease synchrony and validate system reproducibility between experiments is described and will have value in any studies using biological systems that contain dynamic variance associated with large compositional changes in sample matrix over time.
Journal ArticleDOI
Preprocessing, classification modeling and feature selection using flow injection electrospray mass spectrometry metabolite fingerprint data
David Enot,Wanchang Lin,Manfred Beckmann,David A. Parker,David P. Overy,David P. Overy,John Draper +6 more
TL;DR: Data preprocessing and modeling methods that have proved reliable in projects involving samples from a range of organisms, including metabolomics, are described and the salient features of both poor and robust multivariate models are outlined.
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Aspirin Recapitulates Features of Caloric Restriction.
Federico Pietrocola,Francesca Castoldi,Maria Markaki,Sylvie Lachkar,Guo Chen,David Enot,Sylvère Durand,Noélie Bossut,Mingming Tong,Shoaib Ahmad Malik,Friedemann Loos,Nicolas Dupont,Guillermo Mariño,Nejma Abdelkader,Frank Madeo,Maria Chiara Maiuri,Romano T. Kroemer,Patrice Codogno,Junichi Sadoshima,Nektarios Tavernarakis,Guido Kroemer +20 more
TL;DR: It is shown that aspirin or its active metabolite salicylate induce autophagy by virtue of their capacity to inhibit the acetyltransferase activity of EP300, and this findings identify aspirin as an evolutionary conserved CRM.
Journal ArticleDOI
The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer.
Sylvain Ladoire,David Enot,Laura Senovilla,François Ghiringhelli,Vichnou Poirier-Colame,Kariman Chaba,Michaela Semeraro,Marie Chaix,Frédérique Penault-Llorca,Laurent Arnould,Marie Laure Poillot,Patrick Arveux,Suzette Delaloge,Fabrice Andre,Laurence Zitvogel,Guido Kroemer +15 more
TL;DR: Combined analysis of LC3B puncta and HMGB1 expression allowed for improved stratification of patients with respect to the characteristics of their immune infiltrate as well as overall and metastasis-free survival.