David G. Knowles

TL;DR: The most complete human lncRNA annotation to date is presented, produced by the GENCODE consortium within the framework of the ENCODE project and comprising 9277 manually annotated genes producing 14,880 transcripts, and expression correlation analysis indicates that lncRNAs show particularly striking positive correlation with the expression of antisense coding genes.

TL;DR: An overview of the project and the resources it is generating and the application of ENCODE data to interpret the human genome are provided.

TL;DR: A fast mapping-based algorithm is presented to compute the mappability of each region of a reference genome up to a specified number of mismatches, highlighting mappable as an important concept which deserves to be taken into full account when massively parallel sequencing technologies are employed.

TL;DR: The coSI measure, based on RNA-seq reads mapping to exon junctions and borders, is introduced, to assess the degree of splicing completion around internal exons, and significant enrichment of spliceosomal snRNAs in chromatin-associated RNA is found compared with other cellular RNA fractions and other nonspliceosome sn RNAs.

TL;DR: Evidence is presented for the de novo origin of at least three human protein-coding genes since the divergence with chimp, the first evidence for entirely novel human-specific protein-Coding genes originating from ancestrally noncoding sequences.